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A meta-analysis of lipid peroxidation markers in major depression
BACKGROUND: Major depressive disorder (MDD) may be associated with oxidative damage to lipids, which can potentially affect mood-regulating pathways. This meta-analysis summarizes current knowledge regarding lipid peroxidation markers in clinical samples of MDD and the effects of antidepressant phar...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599178/ https://www.ncbi.nlm.nih.gov/pubmed/26491326 http://dx.doi.org/10.2147/NDT.S89922 |
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author | Mazereeuw, Graham Herrmann, Nathan Andreazza, Ana C Khan, Maisha M Lanctôt, Krista L |
author_facet | Mazereeuw, Graham Herrmann, Nathan Andreazza, Ana C Khan, Maisha M Lanctôt, Krista L |
author_sort | Mazereeuw, Graham |
collection | PubMed |
description | BACKGROUND: Major depressive disorder (MDD) may be associated with oxidative damage to lipids, which can potentially affect mood-regulating pathways. This meta-analysis summarizes current knowledge regarding lipid peroxidation markers in clinical samples of MDD and the effects of antidepressant pharmacotherapy on those markers. METHODS: MEDLINE, EMBASE, CINAHL, PsycINFO, and Cochrane Collaboration were searched for original, peer-reviewed articles measuring markers of lipid peroxidation in patients with MDD and nondepressed healthy controls up to April 2015. Standardized mean differences (SMDs) were generated from random effects models summarizing mean (± standard deviations) concentrations of selected markers. RESULTS: Lipid peroxidation was greater in MDD than in controls (studies =17, N=857 MDD/782 control, SMD =0.83 [0.56–1.09], z=6.11, P<0.01, I(2)=84.0%) and was correlated with greater depressive symptom severity (B=0.05, df=8, P<0.01). Antidepressant treatment was associated with a reduction in lipid peroxidation in MDD patients (studies=5, N=222, SMD=0.71 [0.40–0.97], P<0.01; I(2)=42.5%). LIMITATIONS: Lipid peroxidation markers were sampled from peripheral blood, included studies comparing MDD to controls were all cross-sectional, and only five antidepressant treatment studies were eligible for inclusion. CONCLUSION: Increased lipid peroxidation was associated with MDD and may be normalized by antidepressants. Continued investigation of lipid peroxidation in MDD is warranted. |
format | Online Article Text |
id | pubmed-4599178 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-45991782015-10-21 A meta-analysis of lipid peroxidation markers in major depression Mazereeuw, Graham Herrmann, Nathan Andreazza, Ana C Khan, Maisha M Lanctôt, Krista L Neuropsychiatr Dis Treat Review BACKGROUND: Major depressive disorder (MDD) may be associated with oxidative damage to lipids, which can potentially affect mood-regulating pathways. This meta-analysis summarizes current knowledge regarding lipid peroxidation markers in clinical samples of MDD and the effects of antidepressant pharmacotherapy on those markers. METHODS: MEDLINE, EMBASE, CINAHL, PsycINFO, and Cochrane Collaboration were searched for original, peer-reviewed articles measuring markers of lipid peroxidation in patients with MDD and nondepressed healthy controls up to April 2015. Standardized mean differences (SMDs) were generated from random effects models summarizing mean (± standard deviations) concentrations of selected markers. RESULTS: Lipid peroxidation was greater in MDD than in controls (studies =17, N=857 MDD/782 control, SMD =0.83 [0.56–1.09], z=6.11, P<0.01, I(2)=84.0%) and was correlated with greater depressive symptom severity (B=0.05, df=8, P<0.01). Antidepressant treatment was associated with a reduction in lipid peroxidation in MDD patients (studies=5, N=222, SMD=0.71 [0.40–0.97], P<0.01; I(2)=42.5%). LIMITATIONS: Lipid peroxidation markers were sampled from peripheral blood, included studies comparing MDD to controls were all cross-sectional, and only five antidepressant treatment studies were eligible for inclusion. CONCLUSION: Increased lipid peroxidation was associated with MDD and may be normalized by antidepressants. Continued investigation of lipid peroxidation in MDD is warranted. Dove Medical Press 2015-09-29 /pmc/articles/PMC4599178/ /pubmed/26491326 http://dx.doi.org/10.2147/NDT.S89922 Text en © 2015 Mazereeuw et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Mazereeuw, Graham Herrmann, Nathan Andreazza, Ana C Khan, Maisha M Lanctôt, Krista L A meta-analysis of lipid peroxidation markers in major depression |
title | A meta-analysis of lipid peroxidation markers in major depression |
title_full | A meta-analysis of lipid peroxidation markers in major depression |
title_fullStr | A meta-analysis of lipid peroxidation markers in major depression |
title_full_unstemmed | A meta-analysis of lipid peroxidation markers in major depression |
title_short | A meta-analysis of lipid peroxidation markers in major depression |
title_sort | meta-analysis of lipid peroxidation markers in major depression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599178/ https://www.ncbi.nlm.nih.gov/pubmed/26491326 http://dx.doi.org/10.2147/NDT.S89922 |
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