Ca(2+)/calmodulin-dependent protein kinase IIγ enhances stem-like traits and tumorigenicity of lung cancer cells

Highly tumorigenic stem-like cells, considered tumor-initiating cells (TICs), are the main cause of lung cancer initiation, relapse, and drug resistance. In this study, we identified that Ca(2+)/calmodulin-dependent protein kinase IIγ (CaMKIIγ) was aberrantly expressed in highly tumorigenic stem-lik...

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Autores principales: Chai, Shoujie, Xu, Xia, Wang, Yongfang, Zhou, You, Zhang, Chenchen, Yang, Yiming, Yang, Ying, Xu, Haiyan, Xu, Rongzhen, Wang, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599257/
https://www.ncbi.nlm.nih.gov/pubmed/25965829
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author Chai, Shoujie
Xu, Xia
Wang, Yongfang
Zhou, You
Zhang, Chenchen
Yang, Yiming
Yang, Ying
Xu, Haiyan
Xu, Rongzhen
Wang, Kai
author_facet Chai, Shoujie
Xu, Xia
Wang, Yongfang
Zhou, You
Zhang, Chenchen
Yang, Yiming
Yang, Ying
Xu, Haiyan
Xu, Rongzhen
Wang, Kai
author_sort Chai, Shoujie
collection PubMed
description Highly tumorigenic stem-like cells, considered tumor-initiating cells (TICs), are the main cause of lung cancer initiation, relapse, and drug resistance. In this study, we identified that Ca(2+)/calmodulin-dependent protein kinase IIγ (CaMKIIγ) was aberrantly expressed in highly tumorigenic stem-like lung cancer cells, and was also correlated with poor prognosis in human lung cancer. Functionally, CaMKIIγ enhanced stem-like traits and the tumorigenicity of lung cancer cells in an Akt- and β-catenin-dependent manner. In addition, we found that CaMKIIγ upregulated Oct4 expression via Akt-mediated histone acetylation. Taken together, our findings reveal a critical role of CaMKIIγ in regulating the stemness and tumorigenicity of lung cancer cells and offer a promising therapeutic target for TICs.
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spelling pubmed-45992572015-10-26 Ca(2+)/calmodulin-dependent protein kinase IIγ enhances stem-like traits and tumorigenicity of lung cancer cells Chai, Shoujie Xu, Xia Wang, Yongfang Zhou, You Zhang, Chenchen Yang, Yiming Yang, Ying Xu, Haiyan Xu, Rongzhen Wang, Kai Oncotarget Research Paper Highly tumorigenic stem-like cells, considered tumor-initiating cells (TICs), are the main cause of lung cancer initiation, relapse, and drug resistance. In this study, we identified that Ca(2+)/calmodulin-dependent protein kinase IIγ (CaMKIIγ) was aberrantly expressed in highly tumorigenic stem-like lung cancer cells, and was also correlated with poor prognosis in human lung cancer. Functionally, CaMKIIγ enhanced stem-like traits and the tumorigenicity of lung cancer cells in an Akt- and β-catenin-dependent manner. In addition, we found that CaMKIIγ upregulated Oct4 expression via Akt-mediated histone acetylation. Taken together, our findings reveal a critical role of CaMKIIγ in regulating the stemness and tumorigenicity of lung cancer cells and offer a promising therapeutic target for TICs. Impact Journals LLC 2015-04-19 /pmc/articles/PMC4599257/ /pubmed/25965829 Text en Copyright: © 2015 Chai et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Chai, Shoujie
Xu, Xia
Wang, Yongfang
Zhou, You
Zhang, Chenchen
Yang, Yiming
Yang, Ying
Xu, Haiyan
Xu, Rongzhen
Wang, Kai
Ca(2+)/calmodulin-dependent protein kinase IIγ enhances stem-like traits and tumorigenicity of lung cancer cells
title Ca(2+)/calmodulin-dependent protein kinase IIγ enhances stem-like traits and tumorigenicity of lung cancer cells
title_full Ca(2+)/calmodulin-dependent protein kinase IIγ enhances stem-like traits and tumorigenicity of lung cancer cells
title_fullStr Ca(2+)/calmodulin-dependent protein kinase IIγ enhances stem-like traits and tumorigenicity of lung cancer cells
title_full_unstemmed Ca(2+)/calmodulin-dependent protein kinase IIγ enhances stem-like traits and tumorigenicity of lung cancer cells
title_short Ca(2+)/calmodulin-dependent protein kinase IIγ enhances stem-like traits and tumorigenicity of lung cancer cells
title_sort ca(2+)/calmodulin-dependent protein kinase iiγ enhances stem-like traits and tumorigenicity of lung cancer cells
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599257/
https://www.ncbi.nlm.nih.gov/pubmed/25965829
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