Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4

This study explored the role of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in the production of ROS and tumor invasion. UCH-L1 was found to increase cellular ROS levels and promote cell invasion. Silencing UCH-L1, as well as inhibition of H(2)O(2) generation by catalase or by DPI, a NOX inhibitor, s...

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Detalles Bibliográficos
Autores principales: Kim, Hyun Jung, Magesh, Venkataraman, Lee, Jae-Jin, Kim, Sun, Knaus, Ulla G., Lee, Kong-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599270/
https://www.ncbi.nlm.nih.gov/pubmed/25915537

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