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Nuclear EGFR impairs ASPP2-p53 complex-induced apoptosis by inducing SOS1 expression in hepatocellular carcinoma

ASPP2 can bind to p53 and enhance the apoptotic capabilities of p53 by guiding it to the promoters of pro-apoptotic genes. Here, ASPP2 overexpression for 24 hours transiently induced apoptosis in hepatoma cells by enhancing the transactivation of p53 on pro-apoptotic gene promoters. However, long-te...

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Detalles Bibliográficos
Autores principales:	Liu, Kai, Jiang, Tao, Ouyang, Yabo, Shi, Ying, Zang, Yunjin, Li, Ning, Lu, Shichun, Chen, Dexi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599285/ https://www.ncbi.nlm.nih.gov/pubmed/25980493

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