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Inhibition of IGF1-R overcomes IGFBP7-induced chemotherapy resistance in T-ALL

BACKGROUND: T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease with the need for treatment optimization. Previously, high expression of Insulin-like growth factor binding protein 7 (IGFBP7), a member of the IGF system, was identified as negative prognostic factor in a...

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Detalles Bibliográficos
Autores principales:	Bartram, Isabelle, Erben, Ulrike, Ortiz-Tanchez, Jutta, Blunert, Katja, Schlee, Cornelia, Neumann, Martin, Heesch, Sandra, Baldus, Claudia D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599323/ https://www.ncbi.nlm.nih.gov/pubmed/26450156 http://dx.doi.org/10.1186/s12885-015-1677-z

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