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Deficits in tongue motor control are linked to microstructural brain damage in multiple sclerosis: a pilot study
BACKGROUND: Deterioration of fine motor control of the tongue is common in Multiple Sclerosis (MS) and has a major impact on quality of life. However, the underlying neuronal substrate is largely unknown. Here, we aimed to explore the association of tongue motor dysfunction in MS patients with overa...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599335/ https://www.ncbi.nlm.nih.gov/pubmed/26450403 http://dx.doi.org/10.1186/s12883-015-0451-9 |
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author | Holtbernd, Florian Deppe, Michael Bachmann, Rainald Mohammadi, Siawoosh Ringelstein, Erich B. Reilmann, Ralf |
author_facet | Holtbernd, Florian Deppe, Michael Bachmann, Rainald Mohammadi, Siawoosh Ringelstein, Erich B. Reilmann, Ralf |
author_sort | Holtbernd, Florian |
collection | PubMed |
description | BACKGROUND: Deterioration of fine motor control of the tongue is common in Multiple Sclerosis (MS) and has a major impact on quality of life. However, the underlying neuronal substrate is largely unknown. Here, we aimed to explore the association of tongue motor dysfunction in MS patients with overall clinical disability and structural brain damage. METHODS: We employed a force transducer based quantitative-motor system (Q-Motor) to objectively assess tongue function in 33 patients with MS. The variability of tongue force output (TFV) and the mean applied tongue force (TF) were measured during an isometric tongue protrusion task. Twenty-three age and gender matched healthy volunteers served as controls. Correlation analyses of motor performance in MS patients with individual disease burden as expressed by the Expanded Disability Status Scale (EDSS) and with microstructural brain damage as measured by the fractional anisotropy (FA) on Diffusion Tensor Imaging were performed. RESULTS: MS patients showed significantly increased TFV and decreased TF compared to controls (p < 0.02). TFV but not TF was correlated with the EDSS (p < 0.04). TFV was inversely correlated with FA in the bilateral posterior limb of the internal capsule expanding to the brain stem (p < 0.001), a region critical to tongue function. TF showed a weaker, positive and unilateral correlation with FA in the same region (p < 0.001). CONCLUSIONS: Changes in TFV were more robust and correlated better with disease phenotype and FA changes than TF. TFV might serve as an objective and non-invasive outcome measure to augment the quantitative assessment of motor dysfunction in MS. |
format | Online Article Text |
id | pubmed-4599335 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45993352015-10-10 Deficits in tongue motor control are linked to microstructural brain damage in multiple sclerosis: a pilot study Holtbernd, Florian Deppe, Michael Bachmann, Rainald Mohammadi, Siawoosh Ringelstein, Erich B. Reilmann, Ralf BMC Neurol Research Article BACKGROUND: Deterioration of fine motor control of the tongue is common in Multiple Sclerosis (MS) and has a major impact on quality of life. However, the underlying neuronal substrate is largely unknown. Here, we aimed to explore the association of tongue motor dysfunction in MS patients with overall clinical disability and structural brain damage. METHODS: We employed a force transducer based quantitative-motor system (Q-Motor) to objectively assess tongue function in 33 patients with MS. The variability of tongue force output (TFV) and the mean applied tongue force (TF) were measured during an isometric tongue protrusion task. Twenty-three age and gender matched healthy volunteers served as controls. Correlation analyses of motor performance in MS patients with individual disease burden as expressed by the Expanded Disability Status Scale (EDSS) and with microstructural brain damage as measured by the fractional anisotropy (FA) on Diffusion Tensor Imaging were performed. RESULTS: MS patients showed significantly increased TFV and decreased TF compared to controls (p < 0.02). TFV but not TF was correlated with the EDSS (p < 0.04). TFV was inversely correlated with FA in the bilateral posterior limb of the internal capsule expanding to the brain stem (p < 0.001), a region critical to tongue function. TF showed a weaker, positive and unilateral correlation with FA in the same region (p < 0.001). CONCLUSIONS: Changes in TFV were more robust and correlated better with disease phenotype and FA changes than TF. TFV might serve as an objective and non-invasive outcome measure to augment the quantitative assessment of motor dysfunction in MS. BioMed Central 2015-10-08 /pmc/articles/PMC4599335/ /pubmed/26450403 http://dx.doi.org/10.1186/s12883-015-0451-9 Text en © Holtbernd et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Holtbernd, Florian Deppe, Michael Bachmann, Rainald Mohammadi, Siawoosh Ringelstein, Erich B. Reilmann, Ralf Deficits in tongue motor control are linked to microstructural brain damage in multiple sclerosis: a pilot study |
title | Deficits in tongue motor control are linked to microstructural brain damage in multiple sclerosis: a pilot study |
title_full | Deficits in tongue motor control are linked to microstructural brain damage in multiple sclerosis: a pilot study |
title_fullStr | Deficits in tongue motor control are linked to microstructural brain damage in multiple sclerosis: a pilot study |
title_full_unstemmed | Deficits in tongue motor control are linked to microstructural brain damage in multiple sclerosis: a pilot study |
title_short | Deficits in tongue motor control are linked to microstructural brain damage in multiple sclerosis: a pilot study |
title_sort | deficits in tongue motor control are linked to microstructural brain damage in multiple sclerosis: a pilot study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599335/ https://www.ncbi.nlm.nih.gov/pubmed/26450403 http://dx.doi.org/10.1186/s12883-015-0451-9 |
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