Cargando…

Increased Heme Levels in the Heart Lead to Exacerbated Ischemic Injury

BACKGROUND: Heme is an essential iron-containing molecule for cardiovascular physiology, but in excess it may increase oxidative stress. Failing human hearts have increased heme levels, with upregulation of the rate-limiting enzyme in heme synthesis, δ-aminolevulinic acid synthase 2 (ALAS2), which i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sawicki, Konrad Teodor, Shang, Meng, Wu, Rongxue, Chang, Hsiang-Chun, Khechaduri, Arineh, Sato, Tatsuya, Kamide, Christine, Liu, Ting, Naga Prasad, Sathyamangla V, Ardehali, Hossein
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599478/ https://www.ncbi.nlm.nih.gov/pubmed/26231844 http://dx.doi.org/10.1161/JAHA.115.002272

Ejemplares similares

MicroRNA‐210 Decreases heme Levels by Targeting Ferrochelatase in Cardiomyocytes
por: Qiao, Aijun, et al.
Publicado: (2013)

Role of Heme in Cardiovascular Physiology and Disease
por: Sawicki, Konrad Teodor, et al.
Publicado: (2015)

Optimized protocol for quantification of mitochondrial non-heme and heme iron content in mouse tissues and cultured cells
por: Sato, Tatsuya, et al.
Publicado: (2023)

Reduction in mitochondrial iron alleviates cardiac damage during injury
por: Chang, Hsiang‐Chun, et al.
Publicado: (2016)

Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
por: Rines, Amy K., et al.
Publicado: (2017)

Corrigendum: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
por: Rines, Amy K., et al.
Publicado: (2017)

Taking Diabetes to Heart—Deregulation of Myocardial Lipid Metabolism in Diabetic Cardiomyopathy
por: Bayeva, Marina, et al.
Publicado: (2013)

SIRT2 inhibition protects against cardiac hypertrophy and ischemic injury
por: Yang, Xiaoyan, et al.
Publicado: (2023)

Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8
por: Chang, Hsiang-Chun, et al.
Publicado: (2021)

Metabolic Suppression of HIF-1α Contributes to Susceptibility of Ischemic Injury in Diabetic Hearts
por: De Jesus, Adam, et al.
Publicado: (2018)

Potential Role of microRNAs in Cardiovascular Disease: Are They up to Their Hype?
por: Duggal, Bhanu, et al.
Publicado: (2016)

Anthracycline Cardiotoxicity Is Associated With Elevated β1‐Adrenergic Receptor Density
por: Gupta, Manveen K., et al.
Publicado: (2022)

Aging is associated with increased brain iron through cortex-derived hepcidin expression
por: Sato, Tatsuya, et al.
Publicado: (2022)

Regulation and Cytoprotective Role of Hexokinase III
por: Wyatt, Eugene, et al.
Publicado: (2010)

Local and global chromatin interactions are altered by large genomic deletions associated with human brain development
por: Zhang, Xianglong, et al.
Publicado: (2018)

Toll-like receptor 2 deficiency leads to delayed exacerbation of ischemic injury
por: Bohacek, Ivan, et al.
Publicado: (2012)

Free heme exacerbates colonic injury induced by anti-cancer therapy
por: Seika, Philippa, et al.
Publicado: (2023)

G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation
por: Tirupula, Kalyan C., et al.
Publicado: (2015)

Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production
por: Wu, Rongxue, et al.
Publicado: (2012)

Heme Oxygenase-1: Clinical Relevance in Ischemic Stroke
por: Bereczki, Daniel, et al.
Publicado: (2018)

Phosphoinositide 3-kinase regulates β2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/β-arrestin complex
por: Naga Prasad, Sathyamangla V., et al.
Publicado: (2002)

Inhibition of Heme Oxygenase Antioxidant Activity Exacerbates Hepatic Steatosis and Fibrosis In Vitro
por: Raffaele, Marco, et al.
Publicado: (2019)

Clinical Metabolomic Landscape of Cardiovascular Physiology and Disease
por: Fine, Keenan S., et al.
Publicado: (2023)

Iron and Sex Cross Paths in the Heart
por: Shapiro, Jason S., et al.
Publicado: (2017)

Heme oxygenase-1 improves the survival of ischemic skin flaps
por: Zheng, Yinhua, et al.
Publicado: (2021)

Heme oxygenase-1 deficiency exacerbates angiotensin II-induced aortic aneurysm in mice
por: Ho, Yen-Chun, et al.
Publicado: (2016)

Defective Resensitization in Human Airway Smooth Muscle Cells Evokes β-Adrenergic Receptor Dysfunction in Severe Asthma
por: Gupta, Manveen K., et al.
Publicado: (2015)

Noncanonical regulation of insulin-mediated ERK activation by phosphoinositide 3-kinase γ
por: Mohan, Maradumane L., et al.
Publicado: (2017)

Heme Utilization by Pathogenic Bacteria: Not All Pathways Lead to Biliverdin
por: Wilks, Angela, et al.
Publicado: (2014)

The Role of Heme Oxygenase-1 in Remote Ischemic and Anesthetic Organ Conditioning
por: Bauer, Inge, et al.
Publicado: (2019)

Exacerbation of Neonatal Hemolysis and Impaired Renal Iron Handling in Heme Oxygenase 1-Deficient Mice
por: Bednarz, Aleksandra, et al.
Publicado: (2020)

Reversible Biventricular Heart Failure Due to Primary Adrenal Insufficiency
por: Devareddy, Ankita, et al.
Publicado: (2020)

SGLT2 Inhibition on Cardiac Mitochondrial Function: Searching for a Sweet Spot
por: Sawicki, Konrad Teodor, et al.
Publicado: (2021)

Targeting Endothelial HIF2α/ARNT Expression for Ischemic Heart Disease Therapy
por: Ullah, Karim, et al.
Publicado: (2023)

Podocyte-targeted Heme Oxygenase (HO)-1 overexpression exacerbates age-related pathology in the rat kidney
por: Poulaki, Elpida, et al.
Publicado: (2020)

Aging exacerbates neutrophil pathogenicity in ischemic stroke
por: Roy-O’Reilly, Meaghan A., et al.
Publicado: (2020)

My journey to ASCI: why ASCI is so important to me
por: Ardehali, Hossein
Publicado: (2022)

Evidence That the EphA2 Receptor Exacerbates Ischemic Brain Injury
por: Thundyil, John, et al.
Publicado: (2013)

The IgG3 subclass of β1-adrenergic receptor autoantibodies is an endogenous biaser of β1AR signaling
por: Mohan, Maradumane L., et al.
Publicado: (2021)

Bone Fracture Pre-Ischemic Stroke Exacerbates Ischemic Cerebral Injury in Mice
por: Wang, Liang, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_v0ehi3pbg2kqndnv6jcch6r0v7