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Nocturnal eating disturbs phosphorus excretion in young subjects: a randomized crossover trial

BACKGROUND: Nocturnal eating have recently increased. Serum phosphorus levels and regulators of phosphorus have circadian variations, so it is suggested that the timing of eating may be important in controlling serum phosphorus levels. However, there have been no reports on the effects of nocturnal...

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Autores principales: Sakuma, Masae, Noda, Saaya, Morimoto, Yuuka, Suzuki, Akitsu, Nishino, Kanaho, Ando, Sakiko, Umeda, Minako, Ishikawa, Makoto, Arai, Hidekazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599584/
https://www.ncbi.nlm.nih.gov/pubmed/26450680
http://dx.doi.org/10.1186/s12937-015-0096-y
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author Sakuma, Masae
Noda, Saaya
Morimoto, Yuuka
Suzuki, Akitsu
Nishino, Kanaho
Ando, Sakiko
Umeda, Minako
Ishikawa, Makoto
Arai, Hidekazu
author_facet Sakuma, Masae
Noda, Saaya
Morimoto, Yuuka
Suzuki, Akitsu
Nishino, Kanaho
Ando, Sakiko
Umeda, Minako
Ishikawa, Makoto
Arai, Hidekazu
author_sort Sakuma, Masae
collection PubMed
description BACKGROUND: Nocturnal eating have recently increased. Serum phosphorus levels and regulators of phosphorus have circadian variations, so it is suggested that the timing of eating may be important in controlling serum phosphorus levels. However, there have been no reports on the effects of nocturnal eating on phosphorus metabolism. The objective was to evaluate the effects of nocturnal eating on phosphorus metabolism. METHODS: Fourteen healthy men participated in two experimental protocols with differing dinner times. The design of this study was a crossover study. The subjects were served test meals three times (breakfast; 07:30 h, lunch; 12:30 h, dinner; 17:30 or 22:30 h) a day. Blood and urine samples were collected to assess diurnal variation until the following morning. RESULTS: The following morning, fasting serum phosphorus levels in the late dinner group were markedly higher than those in the early dinner group (p < 0.001), although serum calcium levels were maintained at approximately constant levels throughout the day in both groups. Fluctuations in urinary calcium excretion were synchronized with the timing of dinner eating, however, fluctuations in urinary phosphorus excretion were not synchronized. Urinary phosphorus excretions at night were inhibited in the late dinner group. In the late dinner group, intact parathyroid hormone levels didn’t decrease, and they were significantly higher in this group compared with the early dinner group at 20:00 h (p = 0.004). The following morning, fasting serum fibroblast growth factor 23 levels in the late dinner group had not changed, but those in the early dinner group were significantly increased (p = 0.003). Serum free fatty acid levels before dinner were significantly higher in the late dinner group compared with the early dinner group. CONCLUSIONS: Our results indicate that nocturnal eating inhibits phosphorus excretion. It is suggested that nocturnal eating should be abstained from to manage serum phosphorus levels to within an adequate range.
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spelling pubmed-45995842015-10-10 Nocturnal eating disturbs phosphorus excretion in young subjects: a randomized crossover trial Sakuma, Masae Noda, Saaya Morimoto, Yuuka Suzuki, Akitsu Nishino, Kanaho Ando, Sakiko Umeda, Minako Ishikawa, Makoto Arai, Hidekazu Nutr J Research BACKGROUND: Nocturnal eating have recently increased. Serum phosphorus levels and regulators of phosphorus have circadian variations, so it is suggested that the timing of eating may be important in controlling serum phosphorus levels. However, there have been no reports on the effects of nocturnal eating on phosphorus metabolism. The objective was to evaluate the effects of nocturnal eating on phosphorus metabolism. METHODS: Fourteen healthy men participated in two experimental protocols with differing dinner times. The design of this study was a crossover study. The subjects were served test meals three times (breakfast; 07:30 h, lunch; 12:30 h, dinner; 17:30 or 22:30 h) a day. Blood and urine samples were collected to assess diurnal variation until the following morning. RESULTS: The following morning, fasting serum phosphorus levels in the late dinner group were markedly higher than those in the early dinner group (p < 0.001), although serum calcium levels were maintained at approximately constant levels throughout the day in both groups. Fluctuations in urinary calcium excretion were synchronized with the timing of dinner eating, however, fluctuations in urinary phosphorus excretion were not synchronized. Urinary phosphorus excretions at night were inhibited in the late dinner group. In the late dinner group, intact parathyroid hormone levels didn’t decrease, and they were significantly higher in this group compared with the early dinner group at 20:00 h (p = 0.004). The following morning, fasting serum fibroblast growth factor 23 levels in the late dinner group had not changed, but those in the early dinner group were significantly increased (p = 0.003). Serum free fatty acid levels before dinner were significantly higher in the late dinner group compared with the early dinner group. CONCLUSIONS: Our results indicate that nocturnal eating inhibits phosphorus excretion. It is suggested that nocturnal eating should be abstained from to manage serum phosphorus levels to within an adequate range. BioMed Central 2015-10-08 /pmc/articles/PMC4599584/ /pubmed/26450680 http://dx.doi.org/10.1186/s12937-015-0096-y Text en © Sakuma et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Sakuma, Masae
Noda, Saaya
Morimoto, Yuuka
Suzuki, Akitsu
Nishino, Kanaho
Ando, Sakiko
Umeda, Minako
Ishikawa, Makoto
Arai, Hidekazu
Nocturnal eating disturbs phosphorus excretion in young subjects: a randomized crossover trial
title Nocturnal eating disturbs phosphorus excretion in young subjects: a randomized crossover trial
title_full Nocturnal eating disturbs phosphorus excretion in young subjects: a randomized crossover trial
title_fullStr Nocturnal eating disturbs phosphorus excretion in young subjects: a randomized crossover trial
title_full_unstemmed Nocturnal eating disturbs phosphorus excretion in young subjects: a randomized crossover trial
title_short Nocturnal eating disturbs phosphorus excretion in young subjects: a randomized crossover trial
title_sort nocturnal eating disturbs phosphorus excretion in young subjects: a randomized crossover trial
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599584/
https://www.ncbi.nlm.nih.gov/pubmed/26450680
http://dx.doi.org/10.1186/s12937-015-0096-y
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