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Knockdown of interleukin-10 induces the redistribution of sigma1-receptor and increases the glutamate-dependent NADPH-oxidase activity in mouse brain neurons

BACKGROUND: In the central nervous system, interleukin-10 (IL-10) provides trophic and survival effects directly on neurons, modulates neurite plasticity, and has a pivotal importance in the neuronal regeneration in neurodegenerative and neuroinflammatory conditions. This cytokine is primarily produ...

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Detalles Bibliográficos
Autores principales: Koriauli, S., Natsvlishvili, N., Barbakadze, T., Mikeladze, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599652/
https://www.ncbi.nlm.nih.gov/pubmed/26453192
http://dx.doi.org/10.1186/s40659-015-0048-1