Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model

Aberrant tau protein accumulation drives neurofibrillary tangle (NFT) formation in several neurodegenerative diseases. Currently, efforts to elucidate pathogenic mechanisms and assess the efficacy of therapeutic targets are limited by constraints of existing models of tauopathy. In order to generate...

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Detalles Bibliográficos
Autores principales: Cook, Casey, Kang, Silvia S., Carlomagno, Yari, Lin, Wen-Lang, Yue, Mei, Kurti, Aishe, Shinohara, Mitsuru, Jansen-West, Karen, Perkerson, Emilie, Castanedes-Casey, Monica, Rousseau, Linda, Phillips, Virginia, Bu, Guojun, Dickson, Dennis W., Petrucelli, Leonard, Fryer, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599677/
https://www.ncbi.nlm.nih.gov/pubmed/26276810
http://dx.doi.org/10.1093/hmg/ddv336

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