Anti-transferrin receptor-modified amphotericin B-loaded PLA–PEG nanoparticles cure Candidal meningitis and reduce drug toxicity

Fatal fungal infections in central nervous system (CNS) can occur through hematogenous spread or direct extension. At present, hydrophobic amphotericin B (AMB) is the most effective antifungal drug in clinical trials. However, AMB is hydrophobic and therefore penetrates poorly into the CNS, and ther...

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Detalles Bibliográficos
Autores principales: Tang, Xiaolong, Liang, Yong, Zhu, Yongqiang, Xie, Chunmei, Yao, Aixia, Chen, Li, Jiang, Qinglin, Liu, Tingting, Wang, Xiaoyu, Qian, Yunyun, Wei, Jia, Ni, Wenxuan, Dai, Jingjing, Jiang, Zhenyou, Hou, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599718/
https://www.ncbi.nlm.nih.gov/pubmed/26491294
http://dx.doi.org/10.2147/IJN.S84656

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