Cofilin1 is involved in hypertension-induced renal damage via the regulation of NF-κB in renal tubular epithelial cells

BACKGROUND: Inflammation mediated by nuclear factor-κB (NF-κB) plays a critical role in the pathogenesis of hypertensive nephropathy (HN). Cytoskeletal remodelling is necessary for the activation of NF-κB. An actin-binding protein, cofilin-1 promotes dynamic alterations to the cytoskeleton by severi...

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Detalles Bibliográficos
Autores principales: Wang, Quan-zhen, Gao, Hai-qing, Liang, Ying, Zhang, Jun, Wang, Jian, Qiu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599745/
https://www.ncbi.nlm.nih.gov/pubmed/26450610
http://dx.doi.org/10.1186/s12967-015-0685-8

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