ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate

In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. To systematically identify genes that modulate cancer cell survival under stresses, we performed genome-wide shRNA screens under hypoxi...

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Detalles Bibliográficos
Autores principales: Keenan, Melissa M., Liu, Beiyu, Tang, Xiaohu, Wu, Jianli, Cyr, Derek, Stevens, Robert D., Ilkayeva, Olga, Huang, Zhiqing, Tollini, Laura A., Murphy, Susan K., Lucas, Joseph, Muoio, Deborah M., Kim, So Young, Chi, Jen-Tsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599891/
https://www.ncbi.nlm.nih.gov/pubmed/26452058
http://dx.doi.org/10.1371/journal.pgen.1005599

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