A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis

Circulating red blood cells (RBCs) are essential for tissue oxygenation and homeostasis. Defective terminal erythropoiesis contributes to decreased generation of RBCs in many disorders. Specifically, ineffective nuclear expulsion (enucleation) during terminal maturation is an obstacle to therapeutic...

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Detalles Bibliográficos
Autores principales: Liang, Raymond, Campreciós, Genís, Kou, Yan, McGrath, Kathleen, Nowak, Roberta, Catherman, Seana, Bigarella, Carolina L., Rimmelé, Pauline, Zhang, Xin, Gnanapragasam, Merlin Nithya, Bieker, James J., Papatsenko, Dmitri, Ma’ayan, Avi, Bresnick, Emery, Fowler, Velia, Palis, James, Ghaffari, Saghi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599908/
https://www.ncbi.nlm.nih.gov/pubmed/26452208
http://dx.doi.org/10.1371/journal.pgen.1005526

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