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Connectivity Homology Enables Inter-Species Network Models of Synthetic Lethality

Synthetic lethality is a genetic interaction wherein two otherwise nonessential genes cause cellular inviability when knocked out simultaneously. Drugs can mimic genetic knock-out effects; therefore, our understanding of promiscuous drugs, polypharmacology-related adverse drug reactions, and multi-d...

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Detalles Bibliográficos
Autores principales:	Jacunski, Alexandra, Dixon, Scott J., Tatonetti, Nicholas P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599967/ https://www.ncbi.nlm.nih.gov/pubmed/26451775 http://dx.doi.org/10.1371/journal.pcbi.1004506

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