CRISPR-Cas9 mediated gene knockout in primary human airway epithelial cells reveals a pro-inflammatory role for MUC18

Targeted knockout of genes in primary human cells using CRISPR-Cas9 mediated genome-editing represents a powerful approach to study gene function and to discern molecular mechanisms underlying complex human diseases. We used lentiviral delivery of CRISPR-Cas9 machinery and conditional reprogramming...

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Detalles Bibliográficos
Autores principales: Chu, Hong Wei, Rios, Cydney, Huang, Chunjian, Wesolowska-Andersen, Agata, Burchard, Esteban G., O'Connor, Brian P., Fingerlin, Tasha E., Nichols, David, Reynolds, Susan D., Seibold, Max A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600011/
https://www.ncbi.nlm.nih.gov/pubmed/26043872
http://dx.doi.org/10.1038/gt.2015.53

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