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Summation of connectivity strengths in the visual cortex reveals stability of neuronal microcircuits after plasticity

BACKGROUND: Within sensory systems, neurons are continuously affected by environmental stimulation. Recently, we showed that, on cell-pair basis, visual adaptation modulates the connectivity strength between similarly tuned neurons to orientation and we suggested that, on a larger scale, the connect...

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Autores principales: Bachatene, Lyes, Bharmauria, Vishal, Cattan, Sarah, Chanauria, Nayan, Rouat, Jean, Molotchnikoff, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600218/
https://www.ncbi.nlm.nih.gov/pubmed/26453336
http://dx.doi.org/10.1186/s12868-015-0203-1
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author Bachatene, Lyes
Bharmauria, Vishal
Cattan, Sarah
Chanauria, Nayan
Rouat, Jean
Molotchnikoff, Stéphane
author_facet Bachatene, Lyes
Bharmauria, Vishal
Cattan, Sarah
Chanauria, Nayan
Rouat, Jean
Molotchnikoff, Stéphane
author_sort Bachatene, Lyes
collection PubMed
description BACKGROUND: Within sensory systems, neurons are continuously affected by environmental stimulation. Recently, we showed that, on cell-pair basis, visual adaptation modulates the connectivity strength between similarly tuned neurons to orientation and we suggested that, on a larger scale, the connectivity strength between neurons forming sub-networks could be maintained after adaptation-induced-plasticity. In the present paper, based on the summation of the connectivity strengths, we sought to examine how, within cell-assemblies, functional connectivity is regulated during an exposure-based adaptation. RESULTS: Using intrinsic optical imaging combined with electrophysiological recordings following the reconfiguration of the maps of the primary visual cortex by long stimulus exposure, we found that within functionally connected cells, the summed connectivity strengths remain almost equal although connections among individual pairs are modified. Neuronal selectivity appears to be strongly associated with neuronal connectivity in a “homeodynamic” manner which maintains the stability of cortical functional relationships after experience-dependent plasticity. CONCLUSIONS: Our results support the “homeostatic plasticity concept” giving new perspectives on how the summation in visual cortex leads to the stability within labile neuronal ensembles, depending on the newly acquired properties by neurons.
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spelling pubmed-46002182015-10-11 Summation of connectivity strengths in the visual cortex reveals stability of neuronal microcircuits after plasticity Bachatene, Lyes Bharmauria, Vishal Cattan, Sarah Chanauria, Nayan Rouat, Jean Molotchnikoff, Stéphane BMC Neurosci Research Article BACKGROUND: Within sensory systems, neurons are continuously affected by environmental stimulation. Recently, we showed that, on cell-pair basis, visual adaptation modulates the connectivity strength between similarly tuned neurons to orientation and we suggested that, on a larger scale, the connectivity strength between neurons forming sub-networks could be maintained after adaptation-induced-plasticity. In the present paper, based on the summation of the connectivity strengths, we sought to examine how, within cell-assemblies, functional connectivity is regulated during an exposure-based adaptation. RESULTS: Using intrinsic optical imaging combined with electrophysiological recordings following the reconfiguration of the maps of the primary visual cortex by long stimulus exposure, we found that within functionally connected cells, the summed connectivity strengths remain almost equal although connections among individual pairs are modified. Neuronal selectivity appears to be strongly associated with neuronal connectivity in a “homeodynamic” manner which maintains the stability of cortical functional relationships after experience-dependent plasticity. CONCLUSIONS: Our results support the “homeostatic plasticity concept” giving new perspectives on how the summation in visual cortex leads to the stability within labile neuronal ensembles, depending on the newly acquired properties by neurons. BioMed Central 2015-10-09 /pmc/articles/PMC4600218/ /pubmed/26453336 http://dx.doi.org/10.1186/s12868-015-0203-1 Text en © Bachatene et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Bachatene, Lyes
Bharmauria, Vishal
Cattan, Sarah
Chanauria, Nayan
Rouat, Jean
Molotchnikoff, Stéphane
Summation of connectivity strengths in the visual cortex reveals stability of neuronal microcircuits after plasticity
title Summation of connectivity strengths in the visual cortex reveals stability of neuronal microcircuits after plasticity
title_full Summation of connectivity strengths in the visual cortex reveals stability of neuronal microcircuits after plasticity
title_fullStr Summation of connectivity strengths in the visual cortex reveals stability of neuronal microcircuits after plasticity
title_full_unstemmed Summation of connectivity strengths in the visual cortex reveals stability of neuronal microcircuits after plasticity
title_short Summation of connectivity strengths in the visual cortex reveals stability of neuronal microcircuits after plasticity
title_sort summation of connectivity strengths in the visual cortex reveals stability of neuronal microcircuits after plasticity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600218/
https://www.ncbi.nlm.nih.gov/pubmed/26453336
http://dx.doi.org/10.1186/s12868-015-0203-1
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