Synthesis of novel galactose functionalized gold nanoparticles and its radiosensitizing mechanism

BACKGROUND: Biocompatible gold nanoparticles (GNPs) are potentially practical and efficient agents in cancer radiotherapy applications. In this study, we demonstrated that GNPs can significantly modulate irradiation response of hepatocellular carcinoma cells in vitro and investigated the underlying...

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Autores principales: Zhu, Chuan-dong, Zheng, Qin, Wang, Li-xue, Xu, Han-Feng, Tong, Jin-long, Zhang, Quan-an, Wan, Yuan, Wu, Jian-qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600275/
https://www.ncbi.nlm.nih.gov/pubmed/26452535
http://dx.doi.org/10.1186/s12951-015-0129-x
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author Zhu, Chuan-dong
Zheng, Qin
Wang, Li-xue
Xu, Han-Feng
Tong, Jin-long
Zhang, Quan-an
Wan, Yuan
Wu, Jian-qing
author_facet Zhu, Chuan-dong
Zheng, Qin
Wang, Li-xue
Xu, Han-Feng
Tong, Jin-long
Zhang, Quan-an
Wan, Yuan
Wu, Jian-qing
author_sort Zhu, Chuan-dong
collection PubMed
description BACKGROUND: Biocompatible gold nanoparticles (GNPs) are potentially practical and efficient agents in cancer radiotherapy applications. In this study, we demonstrated that GNPs can significantly modulate irradiation response of hepatocellular carcinoma cells in vitro and investigated the underlying mechanisms. We co-grafted galactose (GAL) targeting hepatocyte specific asialoglycoprotein receptor and Polyethylene Glycol (PEG) onto GNPs surfaces to increase GNPs targeting specificity and stability. RESULTS: This novel GAL-PEG-GNPs and bare GNPs show similar appearance and cytotoxicity profiles, while more GAL-PEG-GNPs can be effectively uptaken and could enhance cancer cell killing. CONCLUSION: GAL-PEG-GNPs have better radiosensitization to HepG2. The sensitization mechanism of GAL-PEG-GNPs is related to the apoptotic gene process activated by generation of a large amount of free radicals induced by GNPs.
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spelling pubmed-46002752015-10-11 Synthesis of novel galactose functionalized gold nanoparticles and its radiosensitizing mechanism Zhu, Chuan-dong Zheng, Qin Wang, Li-xue Xu, Han-Feng Tong, Jin-long Zhang, Quan-an Wan, Yuan Wu, Jian-qing J Nanobiotechnology Research BACKGROUND: Biocompatible gold nanoparticles (GNPs) are potentially practical and efficient agents in cancer radiotherapy applications. In this study, we demonstrated that GNPs can significantly modulate irradiation response of hepatocellular carcinoma cells in vitro and investigated the underlying mechanisms. We co-grafted galactose (GAL) targeting hepatocyte specific asialoglycoprotein receptor and Polyethylene Glycol (PEG) onto GNPs surfaces to increase GNPs targeting specificity and stability. RESULTS: This novel GAL-PEG-GNPs and bare GNPs show similar appearance and cytotoxicity profiles, while more GAL-PEG-GNPs can be effectively uptaken and could enhance cancer cell killing. CONCLUSION: GAL-PEG-GNPs have better radiosensitization to HepG2. The sensitization mechanism of GAL-PEG-GNPs is related to the apoptotic gene process activated by generation of a large amount of free radicals induced by GNPs. BioMed Central 2015-10-09 /pmc/articles/PMC4600275/ /pubmed/26452535 http://dx.doi.org/10.1186/s12951-015-0129-x Text en © Zhu et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Zhu, Chuan-dong
Zheng, Qin
Wang, Li-xue
Xu, Han-Feng
Tong, Jin-long
Zhang, Quan-an
Wan, Yuan
Wu, Jian-qing
Synthesis of novel galactose functionalized gold nanoparticles and its radiosensitizing mechanism
title Synthesis of novel galactose functionalized gold nanoparticles and its radiosensitizing mechanism
title_full Synthesis of novel galactose functionalized gold nanoparticles and its radiosensitizing mechanism
title_fullStr Synthesis of novel galactose functionalized gold nanoparticles and its radiosensitizing mechanism
title_full_unstemmed Synthesis of novel galactose functionalized gold nanoparticles and its radiosensitizing mechanism
title_short Synthesis of novel galactose functionalized gold nanoparticles and its radiosensitizing mechanism
title_sort synthesis of novel galactose functionalized gold nanoparticles and its radiosensitizing mechanism
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600275/
https://www.ncbi.nlm.nih.gov/pubmed/26452535
http://dx.doi.org/10.1186/s12951-015-0129-x
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