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The impact of extended bed rest on the musculoskeletal system in the critical care environment
Prolonged immobility is harmful with rapid reductions in muscle mass, bone mineral density and impairment in other body systems evident within the first week of bed rest which is further exacerbated in individuals with critical illness. Our understanding of the aetiology and secondary consequences o...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600281/ https://www.ncbi.nlm.nih.gov/pubmed/26457181 http://dx.doi.org/10.1186/s13728-015-0036-7 |
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author | Parry, Selina M. Puthucheary, Zudin A. |
author_facet | Parry, Selina M. Puthucheary, Zudin A. |
author_sort | Parry, Selina M. |
collection | PubMed |
description | Prolonged immobility is harmful with rapid reductions in muscle mass, bone mineral density and impairment in other body systems evident within the first week of bed rest which is further exacerbated in individuals with critical illness. Our understanding of the aetiology and secondary consequences of prolonged immobilization in the critically ill is improving with recent and ongoing research to establish the cause, effect, and best treatment options. This review aims to describe the current literature on bed rest models for examining immobilization-induced changes in the musculoskeletal system and pathophysiology of immobilisation in critical illness including examination of intracellular signalling processes involved. Finally, the review examines the current barriers to early activity and mobilization and potential rehabilitation strategies, which are being, investigated which may reverse the effects of prolonged bed rest. Addressing the deleterious effects of immobilization is a major step in treatment and prevention of the public health issue, that is, critical illness survivorship. |
format | Online Article Text |
id | pubmed-4600281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-46002812015-10-11 The impact of extended bed rest on the musculoskeletal system in the critical care environment Parry, Selina M. Puthucheary, Zudin A. Extrem Physiol Med Review Prolonged immobility is harmful with rapid reductions in muscle mass, bone mineral density and impairment in other body systems evident within the first week of bed rest which is further exacerbated in individuals with critical illness. Our understanding of the aetiology and secondary consequences of prolonged immobilization in the critically ill is improving with recent and ongoing research to establish the cause, effect, and best treatment options. This review aims to describe the current literature on bed rest models for examining immobilization-induced changes in the musculoskeletal system and pathophysiology of immobilisation in critical illness including examination of intracellular signalling processes involved. Finally, the review examines the current barriers to early activity and mobilization and potential rehabilitation strategies, which are being, investigated which may reverse the effects of prolonged bed rest. Addressing the deleterious effects of immobilization is a major step in treatment and prevention of the public health issue, that is, critical illness survivorship. BioMed Central 2015-10-09 /pmc/articles/PMC4600281/ /pubmed/26457181 http://dx.doi.org/10.1186/s13728-015-0036-7 Text en © Parry and Puthucheary. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Parry, Selina M. Puthucheary, Zudin A. The impact of extended bed rest on the musculoskeletal system in the critical care environment |
title | The impact of extended bed rest on the musculoskeletal system in the critical care environment |
title_full | The impact of extended bed rest on the musculoskeletal system in the critical care environment |
title_fullStr | The impact of extended bed rest on the musculoskeletal system in the critical care environment |
title_full_unstemmed | The impact of extended bed rest on the musculoskeletal system in the critical care environment |
title_short | The impact of extended bed rest on the musculoskeletal system in the critical care environment |
title_sort | impact of extended bed rest on the musculoskeletal system in the critical care environment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600281/ https://www.ncbi.nlm.nih.gov/pubmed/26457181 http://dx.doi.org/10.1186/s13728-015-0036-7 |
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