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Secretome profiling of Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by protein kinase A

BACKGROUND: The pathogenic yeast Cryptococcus neoformans causes life-threatening meningoencephalitis in individuals suffering from HIV/AIDS. The cyclic-AMP/protein kinase A (PKA) signal transduction pathway regulates the production of extracellular virulence factors in C. neoformans, but the influen...

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Detalles Bibliográficos
Autores principales:	Geddes, Jennifer M. H., Croll, Daniel, Caza, Mélissa, Stoynov, Nikolay, Foster, Leonard J., Kronstad, James W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600298/ https://www.ncbi.nlm.nih.gov/pubmed/26453029 http://dx.doi.org/10.1186/s12866-015-0532-3

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