Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice

BACKGROUND: Loss of skeletal muscle mass and function in humans is associated with significant morbidity and mortality. The role of myostatin as a key negative regulator of skeletal muscle mass and function has supported the concept that inactivation of myostatin could be a useful approach for treat...

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Detalles Bibliográficos
Autores principales: Latres, Esther, Pangilinan, Jeffrey, Miloscio, Lawrence, Bauerlein, Roy, Na, Erqian, Potocky, Terra B., Huang, Ying, Eckersdorff, Mark, Rafique, Ashique, Mastaitis, Jason, Lin, Calvin, Murphy, Andrew J., Yancopoulos, George D., Gromada, Jesper, Stitt, Trevor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600334/
https://www.ncbi.nlm.nih.gov/pubmed/26457176
http://dx.doi.org/10.1186/s13395-015-0060-8

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