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A case report: retigabine induced oral mucosal dyspigmentation of the hard palate
BACKGROUND: Dyspigmentation of the oral mucosa has a multitude of aetiological causes. Retigabine, a new antiepileptic drug, has the potential side effect of inducing a blue/purple pigmentation of the oral mucosa in addition to the skin, lips, nails and retina of the eyes. This article presents a un...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600339/ https://www.ncbi.nlm.nih.gov/pubmed/26452759 http://dx.doi.org/10.1186/s12903-015-0102-y |
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author | Beacher, Nicholas G. Brodie, Martin J. Goodall, Christine |
author_facet | Beacher, Nicholas G. Brodie, Martin J. Goodall, Christine |
author_sort | Beacher, Nicholas G. |
collection | PubMed |
description | BACKGROUND: Dyspigmentation of the oral mucosa has a multitude of aetiological causes. Retigabine, a new antiepileptic drug, has the potential side effect of inducing a blue/purple pigmentation of the oral mucosa in addition to the skin, lips, nails and retina of the eyes. This article presents a unique case of dyspigmentation present in the oral mucosa of the hard palate which has previously been unreported in the dental literature. CASE PRESENTATION: A 70 year old white male presented to a secondary care oral surgery department with an unusual asymptomatic pigmented lesion present in the hard palate of the oral cavity. The pigmentation was remarkable for its distinct blue/purple colouration which was associated with a similar discolouration of the nail beds of the hands. This is believed to be a side effect of the anti-epileptic medication retigabine. CONCLUSION: The dental profession and wider healthcare community should be made fully aware of the potential side effect of oral dyspigmentation associated with the novel anti-epileptic medication retigabine. Enhanced knowledge of the causative role of retigabine in dyspigementation of the oral mucosa will allow the practitioner to make an appropriate diagnosis. As far the authors are aware this is reaction is unreported in the dental literature and should be disseminated to the wider oral health professional’s community. |
format | Online Article Text |
id | pubmed-4600339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-46003392015-10-11 A case report: retigabine induced oral mucosal dyspigmentation of the hard palate Beacher, Nicholas G. Brodie, Martin J. Goodall, Christine BMC Oral Health Case Report BACKGROUND: Dyspigmentation of the oral mucosa has a multitude of aetiological causes. Retigabine, a new antiepileptic drug, has the potential side effect of inducing a blue/purple pigmentation of the oral mucosa in addition to the skin, lips, nails and retina of the eyes. This article presents a unique case of dyspigmentation present in the oral mucosa of the hard palate which has previously been unreported in the dental literature. CASE PRESENTATION: A 70 year old white male presented to a secondary care oral surgery department with an unusual asymptomatic pigmented lesion present in the hard palate of the oral cavity. The pigmentation was remarkable for its distinct blue/purple colouration which was associated with a similar discolouration of the nail beds of the hands. This is believed to be a side effect of the anti-epileptic medication retigabine. CONCLUSION: The dental profession and wider healthcare community should be made fully aware of the potential side effect of oral dyspigmentation associated with the novel anti-epileptic medication retigabine. Enhanced knowledge of the causative role of retigabine in dyspigementation of the oral mucosa will allow the practitioner to make an appropriate diagnosis. As far the authors are aware this is reaction is unreported in the dental literature and should be disseminated to the wider oral health professional’s community. BioMed Central 2015-10-09 /pmc/articles/PMC4600339/ /pubmed/26452759 http://dx.doi.org/10.1186/s12903-015-0102-y Text en © Beacher et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Beacher, Nicholas G. Brodie, Martin J. Goodall, Christine A case report: retigabine induced oral mucosal dyspigmentation of the hard palate |
title | A case report: retigabine induced oral mucosal dyspigmentation of the hard palate |
title_full | A case report: retigabine induced oral mucosal dyspigmentation of the hard palate |
title_fullStr | A case report: retigabine induced oral mucosal dyspigmentation of the hard palate |
title_full_unstemmed | A case report: retigabine induced oral mucosal dyspigmentation of the hard palate |
title_short | A case report: retigabine induced oral mucosal dyspigmentation of the hard palate |
title_sort | case report: retigabine induced oral mucosal dyspigmentation of the hard palate |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600339/ https://www.ncbi.nlm.nih.gov/pubmed/26452759 http://dx.doi.org/10.1186/s12903-015-0102-y |
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