Cargando…

Cortical Excitability Measured with nTMS and MEG during Stroke Recovery

Objective. Stroke alters cortical excitability both in the lesioned and in the nonlesioned hemisphere. Stroke recovery has been studied using transcranial magnetic stimulation (TMS). Spontaneous brain oscillations and somatosensory evoked fields (SEFs) measured by magnetoencephalography (MEG) are mo...

Descripción completa

Detalles Bibliográficos
Autores principales: Mäkelä, Jyrki P., Lioumis, Pantelis, Laaksonen, Kristina, Forss, Nina, Tatlisumak, Turgut, Kaste, Markku, Mustanoja, Satu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600492/
https://www.ncbi.nlm.nih.gov/pubmed/26491569
http://dx.doi.org/10.1155/2015/309546
_version_ 1782394429110222848
author Mäkelä, Jyrki P.
Lioumis, Pantelis
Laaksonen, Kristina
Forss, Nina
Tatlisumak, Turgut
Kaste, Markku
Mustanoja, Satu
author_facet Mäkelä, Jyrki P.
Lioumis, Pantelis
Laaksonen, Kristina
Forss, Nina
Tatlisumak, Turgut
Kaste, Markku
Mustanoja, Satu
author_sort Mäkelä, Jyrki P.
collection PubMed
description Objective. Stroke alters cortical excitability both in the lesioned and in the nonlesioned hemisphere. Stroke recovery has been studied using transcranial magnetic stimulation (TMS). Spontaneous brain oscillations and somatosensory evoked fields (SEFs) measured by magnetoencephalography (MEG) are modified in stroke patients during recovery. Methods. We recorded SEFs and spontaneous MEG activity and motor threshold (MT) short intracortical inhibition (SICI) and intracortical facilitation (ICF) with navigated TMS (nTMS) at one and three months after first-ever hemispheric ischemic strokes. Changes of MEG and nTMS parameters attributed to gamma-aminobutyrate and glutamate transmission were compared. Results. ICF correlated with the strength and extent of SEF source areas depicted by MEG at three months. The nTMS MT and event-related desynchronization (ERD) of beta-band MEG activity and SICI and the beta-band MEG event-related synchronization (ERS) were correlated, but less strongly. Conclusions. This first report using sequential nTMS and MEG in stroke recovery found intra- and interhemispheric correlations of nTMS and MEG estimates of cortical excitability. ICF and SEF parameters, MT and the ERD of the lesioned hemisphere, and SICI and ERS of the nonlesioned hemisphere were correlated. Covarying excitability in the lesioned and nonlesioned hemispheres emphasizes the importance of the hemispheric balance of the excitability of the sensorimotor system.
format Online
Article
Text
id pubmed-4600492
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-46004922015-10-21 Cortical Excitability Measured with nTMS and MEG during Stroke Recovery Mäkelä, Jyrki P. Lioumis, Pantelis Laaksonen, Kristina Forss, Nina Tatlisumak, Turgut Kaste, Markku Mustanoja, Satu Neural Plast Research Article Objective. Stroke alters cortical excitability both in the lesioned and in the nonlesioned hemisphere. Stroke recovery has been studied using transcranial magnetic stimulation (TMS). Spontaneous brain oscillations and somatosensory evoked fields (SEFs) measured by magnetoencephalography (MEG) are modified in stroke patients during recovery. Methods. We recorded SEFs and spontaneous MEG activity and motor threshold (MT) short intracortical inhibition (SICI) and intracortical facilitation (ICF) with navigated TMS (nTMS) at one and three months after first-ever hemispheric ischemic strokes. Changes of MEG and nTMS parameters attributed to gamma-aminobutyrate and glutamate transmission were compared. Results. ICF correlated with the strength and extent of SEF source areas depicted by MEG at three months. The nTMS MT and event-related desynchronization (ERD) of beta-band MEG activity and SICI and the beta-band MEG event-related synchronization (ERS) were correlated, but less strongly. Conclusions. This first report using sequential nTMS and MEG in stroke recovery found intra- and interhemispheric correlations of nTMS and MEG estimates of cortical excitability. ICF and SEF parameters, MT and the ERD of the lesioned hemisphere, and SICI and ERS of the nonlesioned hemisphere were correlated. Covarying excitability in the lesioned and nonlesioned hemispheres emphasizes the importance of the hemispheric balance of the excitability of the sensorimotor system. Hindawi Publishing Corporation 2015 2015-09-27 /pmc/articles/PMC4600492/ /pubmed/26491569 http://dx.doi.org/10.1155/2015/309546 Text en Copyright © 2015 Jyrki P. Mäkelä et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mäkelä, Jyrki P.
Lioumis, Pantelis
Laaksonen, Kristina
Forss, Nina
Tatlisumak, Turgut
Kaste, Markku
Mustanoja, Satu
Cortical Excitability Measured with nTMS and MEG during Stroke Recovery
title Cortical Excitability Measured with nTMS and MEG during Stroke Recovery
title_full Cortical Excitability Measured with nTMS and MEG during Stroke Recovery
title_fullStr Cortical Excitability Measured with nTMS and MEG during Stroke Recovery
title_full_unstemmed Cortical Excitability Measured with nTMS and MEG during Stroke Recovery
title_short Cortical Excitability Measured with nTMS and MEG during Stroke Recovery
title_sort cortical excitability measured with ntms and meg during stroke recovery
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600492/
https://www.ncbi.nlm.nih.gov/pubmed/26491569
http://dx.doi.org/10.1155/2015/309546
work_keys_str_mv AT makelajyrkip corticalexcitabilitymeasuredwithntmsandmegduringstrokerecovery
AT lioumispantelis corticalexcitabilitymeasuredwithntmsandmegduringstrokerecovery
AT laaksonenkristina corticalexcitabilitymeasuredwithntmsandmegduringstrokerecovery
AT forssnina corticalexcitabilitymeasuredwithntmsandmegduringstrokerecovery
AT tatlisumakturgut corticalexcitabilitymeasuredwithntmsandmegduringstrokerecovery
AT kastemarkku corticalexcitabilitymeasuredwithntmsandmegduringstrokerecovery
AT mustanojasatu corticalexcitabilitymeasuredwithntmsandmegduringstrokerecovery