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A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings

Gender differences in schizophrenia have been extensively researched and it is being increasingly accepted that gonadal steroids are strongly attributed to this phenomenon. Of the various hormones implicated, the estrogen hypothesis has been the most widely researched one and it postulates that estr...

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Autores principales: Gogos, Andrea, Sbisa, Alyssa M., Sun, Jeehae, Gibbons, Andrew, Udawela, Madhara, Dean, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600562/
https://www.ncbi.nlm.nih.gov/pubmed/26491441
http://dx.doi.org/10.1155/2015/615356
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author Gogos, Andrea
Sbisa, Alyssa M.
Sun, Jeehae
Gibbons, Andrew
Udawela, Madhara
Dean, Brian
author_facet Gogos, Andrea
Sbisa, Alyssa M.
Sun, Jeehae
Gibbons, Andrew
Udawela, Madhara
Dean, Brian
author_sort Gogos, Andrea
collection PubMed
description Gender differences in schizophrenia have been extensively researched and it is being increasingly accepted that gonadal steroids are strongly attributed to this phenomenon. Of the various hormones implicated, the estrogen hypothesis has been the most widely researched one and it postulates that estrogen exerts a protective effect by buffering females against the development and severity of the illness. In this review, we comprehensively analyse studies that have investigated the effects of estrogen, in particular 17β-estradiol, in clinical, animal, and molecular research with relevance to schizophrenia. Specifically, we discuss the current evidence on estrogen dysfunction in schizophrenia patients and review the clinical findings on the use of estradiol as an adjunctive treatment in schizophrenia patients. Preclinical research that has used animal models and molecular probes to investigate estradiol's underlying protective mechanisms is also substantially discussed, with particular focus on estradiol's impact on the major neurotransmitter systems implicated in schizophrenia, namely, the dopamine, serotonin, and glutamate systems.
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spelling pubmed-46005622015-10-21 A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings Gogos, Andrea Sbisa, Alyssa M. Sun, Jeehae Gibbons, Andrew Udawela, Madhara Dean, Brian Int J Endocrinol Review Article Gender differences in schizophrenia have been extensively researched and it is being increasingly accepted that gonadal steroids are strongly attributed to this phenomenon. Of the various hormones implicated, the estrogen hypothesis has been the most widely researched one and it postulates that estrogen exerts a protective effect by buffering females against the development and severity of the illness. In this review, we comprehensively analyse studies that have investigated the effects of estrogen, in particular 17β-estradiol, in clinical, animal, and molecular research with relevance to schizophrenia. Specifically, we discuss the current evidence on estrogen dysfunction in schizophrenia patients and review the clinical findings on the use of estradiol as an adjunctive treatment in schizophrenia patients. Preclinical research that has used animal models and molecular probes to investigate estradiol's underlying protective mechanisms is also substantially discussed, with particular focus on estradiol's impact on the major neurotransmitter systems implicated in schizophrenia, namely, the dopamine, serotonin, and glutamate systems. Hindawi Publishing Corporation 2015 2015-09-27 /pmc/articles/PMC4600562/ /pubmed/26491441 http://dx.doi.org/10.1155/2015/615356 Text en Copyright © 2015 Andrea Gogos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gogos, Andrea
Sbisa, Alyssa M.
Sun, Jeehae
Gibbons, Andrew
Udawela, Madhara
Dean, Brian
A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings
title A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings
title_full A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings
title_fullStr A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings
title_full_unstemmed A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings
title_short A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings
title_sort role for estrogen in schizophrenia: clinical and preclinical findings
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600562/
https://www.ncbi.nlm.nih.gov/pubmed/26491441
http://dx.doi.org/10.1155/2015/615356
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