Cargando…
A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings
Gender differences in schizophrenia have been extensively researched and it is being increasingly accepted that gonadal steroids are strongly attributed to this phenomenon. Of the various hormones implicated, the estrogen hypothesis has been the most widely researched one and it postulates that estr...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600562/ https://www.ncbi.nlm.nih.gov/pubmed/26491441 http://dx.doi.org/10.1155/2015/615356 |
_version_ | 1782394443322621952 |
---|---|
author | Gogos, Andrea Sbisa, Alyssa M. Sun, Jeehae Gibbons, Andrew Udawela, Madhara Dean, Brian |
author_facet | Gogos, Andrea Sbisa, Alyssa M. Sun, Jeehae Gibbons, Andrew Udawela, Madhara Dean, Brian |
author_sort | Gogos, Andrea |
collection | PubMed |
description | Gender differences in schizophrenia have been extensively researched and it is being increasingly accepted that gonadal steroids are strongly attributed to this phenomenon. Of the various hormones implicated, the estrogen hypothesis has been the most widely researched one and it postulates that estrogen exerts a protective effect by buffering females against the development and severity of the illness. In this review, we comprehensively analyse studies that have investigated the effects of estrogen, in particular 17β-estradiol, in clinical, animal, and molecular research with relevance to schizophrenia. Specifically, we discuss the current evidence on estrogen dysfunction in schizophrenia patients and review the clinical findings on the use of estradiol as an adjunctive treatment in schizophrenia patients. Preclinical research that has used animal models and molecular probes to investigate estradiol's underlying protective mechanisms is also substantially discussed, with particular focus on estradiol's impact on the major neurotransmitter systems implicated in schizophrenia, namely, the dopamine, serotonin, and glutamate systems. |
format | Online Article Text |
id | pubmed-4600562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46005622015-10-21 A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings Gogos, Andrea Sbisa, Alyssa M. Sun, Jeehae Gibbons, Andrew Udawela, Madhara Dean, Brian Int J Endocrinol Review Article Gender differences in schizophrenia have been extensively researched and it is being increasingly accepted that gonadal steroids are strongly attributed to this phenomenon. Of the various hormones implicated, the estrogen hypothesis has been the most widely researched one and it postulates that estrogen exerts a protective effect by buffering females against the development and severity of the illness. In this review, we comprehensively analyse studies that have investigated the effects of estrogen, in particular 17β-estradiol, in clinical, animal, and molecular research with relevance to schizophrenia. Specifically, we discuss the current evidence on estrogen dysfunction in schizophrenia patients and review the clinical findings on the use of estradiol as an adjunctive treatment in schizophrenia patients. Preclinical research that has used animal models and molecular probes to investigate estradiol's underlying protective mechanisms is also substantially discussed, with particular focus on estradiol's impact on the major neurotransmitter systems implicated in schizophrenia, namely, the dopamine, serotonin, and glutamate systems. Hindawi Publishing Corporation 2015 2015-09-27 /pmc/articles/PMC4600562/ /pubmed/26491441 http://dx.doi.org/10.1155/2015/615356 Text en Copyright © 2015 Andrea Gogos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Gogos, Andrea Sbisa, Alyssa M. Sun, Jeehae Gibbons, Andrew Udawela, Madhara Dean, Brian A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings |
title | A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings |
title_full | A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings |
title_fullStr | A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings |
title_full_unstemmed | A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings |
title_short | A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings |
title_sort | role for estrogen in schizophrenia: clinical and preclinical findings |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600562/ https://www.ncbi.nlm.nih.gov/pubmed/26491441 http://dx.doi.org/10.1155/2015/615356 |
work_keys_str_mv | AT gogosandrea aroleforestrogeninschizophreniaclinicalandpreclinicalfindings AT sbisaalyssam aroleforestrogeninschizophreniaclinicalandpreclinicalfindings AT sunjeehae aroleforestrogeninschizophreniaclinicalandpreclinicalfindings AT gibbonsandrew aroleforestrogeninschizophreniaclinicalandpreclinicalfindings AT udawelamadhara aroleforestrogeninschizophreniaclinicalandpreclinicalfindings AT deanbrian aroleforestrogeninschizophreniaclinicalandpreclinicalfindings AT gogosandrea roleforestrogeninschizophreniaclinicalandpreclinicalfindings AT sbisaalyssam roleforestrogeninschizophreniaclinicalandpreclinicalfindings AT sunjeehae roleforestrogeninschizophreniaclinicalandpreclinicalfindings AT gibbonsandrew roleforestrogeninschizophreniaclinicalandpreclinicalfindings AT udawelamadhara roleforestrogeninschizophreniaclinicalandpreclinicalfindings AT deanbrian roleforestrogeninschizophreniaclinicalandpreclinicalfindings |