Heart-specific Rpd3 downregulation enhances cardiac function and longevity

Downregulation of Rpd3, a homologue of mammalian Histone Deacetylase 1 (HDAC1), extends lifespan in Drosophila melanogaster. Once revealed that long-lived fruit flies exhibit limited cardiac decline, we investigated whether Rpd3 downregulation would improve stress resistance and/or lifespan when tar...

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Detalles Bibliográficos
Autores principales: Kopp, Zachary A., Hsieh, Jo-Lin, Li, Andrew, Wang, William, Bhatt, Dhelni T., Lee, Angela, Kim, Sae Yeon, Fan, David, Shah, Veevek, Siddiqui, Emaad, Ragam, Radhika, Park, Kristen, Ardeshna, Dev, Park, Kunwoo, Wu, Rachel, Parikh, Hardik, Parikh, Ayush, Lin, Yuh-Ru, Park, Yongkyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600623/
https://www.ncbi.nlm.nih.gov/pubmed/26399365

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