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Quantifying the stabilizing effects of protein–ligand interactions in the gas phase

The effects of protein–ligand interactions on protein stability are typically monitored by a number of established solution-phase assays. Few translate readily to membrane proteins. We have developed an ion-mobility mass spectrometry approach, which discerns ligand binding to both soluble and membra...

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Detalles Bibliográficos
Autores principales:	Allison, Timothy M., Reading, Eamonn, Liko, Idlir, Baldwin, Andrew J., Laganowsky, Arthur, Robinson, Carol V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600733/ https://www.ncbi.nlm.nih.gov/pubmed/26440106 http://dx.doi.org/10.1038/ncomms9551

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