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S-nitrosylation in TNF superfamily signaling pathway: Implication in cancer()

One of the key features of tumor cells is the acquisition of resistance to apoptosis. Thus, novel therapeutic strategies that circumvent apoptotic resistance and result in tumor elimination are needed. One strategy to induce apoptosis is to activate death receptor signaling pathways. In the tumor mi...

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Autores principales: Plenchette, Stéphanie, Romagny, Sabrina, Laurens, Véronique, Bettaieb, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600855/
https://www.ncbi.nlm.nih.gov/pubmed/26448396
http://dx.doi.org/10.1016/j.redox.2015.08.019
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author Plenchette, Stéphanie
Romagny, Sabrina
Laurens, Véronique
Bettaieb, Ali
author_facet Plenchette, Stéphanie
Romagny, Sabrina
Laurens, Véronique
Bettaieb, Ali
author_sort Plenchette, Stéphanie
collection PubMed
description One of the key features of tumor cells is the acquisition of resistance to apoptosis. Thus, novel therapeutic strategies that circumvent apoptotic resistance and result in tumor elimination are needed. One strategy to induce apoptosis is to activate death receptor signaling pathways. In the tumor microenvironment, stimulation of Fas, Death receptor 4 (DR4) and tumor necrosis factor receptor 1 (TNFR1) can initiate multiple signaling pathways driving either tumor promotion or elimination. Nitric oxide (NO) is an important signaling molecule now understood to play a dual role in cancer biology. More and more attention is directed toward the role displayed by S-nitrosylation, the incorporation of an NO moiety to a cysteine thiol group, in promoting cell death in tumor cells. Protein post-translation modification by S-nitrosylation has decisive roles in regulating signal-transduction pathways. In this review, we summarize several examples of protein modification by S-nitrosylation that regulate signaling pathways engaged by members of the TNF superfamily (Fas ligand (FasL), Tumor-necrosis-factor-related apoptosis inducing ligand (TRAIL) and TNFalpha (TNFα)) and the way it influences cell fate decisions.
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spelling pubmed-46008552015-11-12 S-nitrosylation in TNF superfamily signaling pathway: Implication in cancer() Plenchette, Stéphanie Romagny, Sabrina Laurens, Véronique Bettaieb, Ali Redox Biol Review Article One of the key features of tumor cells is the acquisition of resistance to apoptosis. Thus, novel therapeutic strategies that circumvent apoptotic resistance and result in tumor elimination are needed. One strategy to induce apoptosis is to activate death receptor signaling pathways. In the tumor microenvironment, stimulation of Fas, Death receptor 4 (DR4) and tumor necrosis factor receptor 1 (TNFR1) can initiate multiple signaling pathways driving either tumor promotion or elimination. Nitric oxide (NO) is an important signaling molecule now understood to play a dual role in cancer biology. More and more attention is directed toward the role displayed by S-nitrosylation, the incorporation of an NO moiety to a cysteine thiol group, in promoting cell death in tumor cells. Protein post-translation modification by S-nitrosylation has decisive roles in regulating signal-transduction pathways. In this review, we summarize several examples of protein modification by S-nitrosylation that regulate signaling pathways engaged by members of the TNF superfamily (Fas ligand (FasL), Tumor-necrosis-factor-related apoptosis inducing ligand (TRAIL) and TNFalpha (TNFα)) and the way it influences cell fate decisions. Elsevier 2015-09-08 /pmc/articles/PMC4600855/ /pubmed/26448396 http://dx.doi.org/10.1016/j.redox.2015.08.019 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Plenchette, Stéphanie
Romagny, Sabrina
Laurens, Véronique
Bettaieb, Ali
S-nitrosylation in TNF superfamily signaling pathway: Implication in cancer()
title S-nitrosylation in TNF superfamily signaling pathway: Implication in cancer()
title_full S-nitrosylation in TNF superfamily signaling pathway: Implication in cancer()
title_fullStr S-nitrosylation in TNF superfamily signaling pathway: Implication in cancer()
title_full_unstemmed S-nitrosylation in TNF superfamily signaling pathway: Implication in cancer()
title_short S-nitrosylation in TNF superfamily signaling pathway: Implication in cancer()
title_sort s-nitrosylation in tnf superfamily signaling pathway: implication in cancer()
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600855/
https://www.ncbi.nlm.nih.gov/pubmed/26448396
http://dx.doi.org/10.1016/j.redox.2015.08.019
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