Altered Basal Ganglia Network Integration in Schizophrenia

The basal ganglia involve in a range of functions that are disturbed in schizophrenia patients. This study decomposed the resting-state data of 28 schizophrenia patients and 31 healthy controls with spatial independent component analysis and identified increased functional integration in the bilater...

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Detalles Bibliográficos
Autores principales: Duan, Mingjun, Chen, Xi, He, Hui, Jiang, Yuchao, Jiang, Sisi, Xie, Qiankun, Lai, Yongxiu, Luo, Cheng, Yao, Dezhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600918/
https://www.ncbi.nlm.nih.gov/pubmed/26528167
http://dx.doi.org/10.3389/fnhum.2015.00561
Descripción
Sumario:The basal ganglia involve in a range of functions that are disturbed in schizophrenia patients. This study decomposed the resting-state data of 28 schizophrenia patients and 31 healthy controls with spatial independent component analysis and identified increased functional integration in the bilateral caudate nucleus in schizophrenia patients. Further, the caudate nucleus in patients showed altered functional connection with the prefrontal area and cerebellum. These results identified the importance of basal ganglia in schizophrenia patients. Clinical Trial Registration: Chinese Clinical Trial Registry. Registration number ChiCTR-RCS-14004878.

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