Altered Basal Ganglia Network Integration in Schizophrenia

The basal ganglia involve in a range of functions that are disturbed in schizophrenia patients. This study decomposed the resting-state data of 28 schizophrenia patients and 31 healthy controls with spatial independent component analysis and identified increased functional integration in the bilater...

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Autores principales: Duan, Mingjun, Chen, Xi, He, Hui, Jiang, Yuchao, Jiang, Sisi, Xie, Qiankun, Lai, Yongxiu, Luo, Cheng, Yao, Dezhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600918/
https://www.ncbi.nlm.nih.gov/pubmed/26528167
http://dx.doi.org/10.3389/fnhum.2015.00561
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author Duan, Mingjun
Chen, Xi
He, Hui
Jiang, Yuchao
Jiang, Sisi
Xie, Qiankun
Lai, Yongxiu
Luo, Cheng
Yao, Dezhong
author_facet Duan, Mingjun
Chen, Xi
He, Hui
Jiang, Yuchao
Jiang, Sisi
Xie, Qiankun
Lai, Yongxiu
Luo, Cheng
Yao, Dezhong
author_sort Duan, Mingjun
collection PubMed
description The basal ganglia involve in a range of functions that are disturbed in schizophrenia patients. This study decomposed the resting-state data of 28 schizophrenia patients and 31 healthy controls with spatial independent component analysis and identified increased functional integration in the bilateral caudate nucleus in schizophrenia patients. Further, the caudate nucleus in patients showed altered functional connection with the prefrontal area and cerebellum. These results identified the importance of basal ganglia in schizophrenia patients. Clinical Trial Registration: Chinese Clinical Trial Registry. Registration number ChiCTR-RCS-14004878.
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spelling pubmed-46009182015-11-02 Altered Basal Ganglia Network Integration in Schizophrenia Duan, Mingjun Chen, Xi He, Hui Jiang, Yuchao Jiang, Sisi Xie, Qiankun Lai, Yongxiu Luo, Cheng Yao, Dezhong Front Hum Neurosci Neuroscience The basal ganglia involve in a range of functions that are disturbed in schizophrenia patients. This study decomposed the resting-state data of 28 schizophrenia patients and 31 healthy controls with spatial independent component analysis and identified increased functional integration in the bilateral caudate nucleus in schizophrenia patients. Further, the caudate nucleus in patients showed altered functional connection with the prefrontal area and cerebellum. These results identified the importance of basal ganglia in schizophrenia patients. Clinical Trial Registration: Chinese Clinical Trial Registry. Registration number ChiCTR-RCS-14004878. Frontiers Media S.A. 2015-10-12 /pmc/articles/PMC4600918/ /pubmed/26528167 http://dx.doi.org/10.3389/fnhum.2015.00561 Text en Copyright © 2015 Duan, Chen, He, Jiang, Jiang, Xie, Lai, Luo and Yao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Duan, Mingjun
Chen, Xi
He, Hui
Jiang, Yuchao
Jiang, Sisi
Xie, Qiankun
Lai, Yongxiu
Luo, Cheng
Yao, Dezhong
Altered Basal Ganglia Network Integration in Schizophrenia
title Altered Basal Ganglia Network Integration in Schizophrenia
title_full Altered Basal Ganglia Network Integration in Schizophrenia
title_fullStr Altered Basal Ganglia Network Integration in Schizophrenia
title_full_unstemmed Altered Basal Ganglia Network Integration in Schizophrenia
title_short Altered Basal Ganglia Network Integration in Schizophrenia
title_sort altered basal ganglia network integration in schizophrenia
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600918/
https://www.ncbi.nlm.nih.gov/pubmed/26528167
http://dx.doi.org/10.3389/fnhum.2015.00561
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