AR Pathway Is Involved in the Regulation of CX43 in Prostate Cancer

CX43 plays a critical role in tumor progression. Previous studies imply that AR pathway may be involved in regulation of CX43. This study was focused on determining the relationship between AR pathway and CX43. The result showed that the expression of CX43 in malignant cells was higher than that in...

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Detalles Bibliográficos
Autores principales: Chen, Ruibao, Luan, Yang, Liu, Zhuo, Song, Wen, Wu, Licheng, Li, Mingchao, Yang, Jun, Liu, Xiaming, Wang, Tao, Liu, Jihong, Ye, Zhangqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600923/
https://www.ncbi.nlm.nih.gov/pubmed/26491675
http://dx.doi.org/10.1155/2015/514234
Descripción
Sumario:CX43 plays a critical role in tumor progression. Previous studies imply that AR pathway may be involved in regulation of CX43. This study was focused on determining the relationship between AR pathway and CX43. The result showed that the expression of CX43 in malignant cells was higher than that in normal cells, and in nonmalignant and malignant cells, not only is the expression level of CX43 different, but the localization of CX43 can also be changed. After androgen stimulation and inhibition of AR pathway, expression of CX43 can also be changed. Thus, AR pathway plays an important role in regulation of CX43 expression in prostate cancer cells. AR may be the upstream signal of CX43.

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