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Single-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexes

Telomerase synthesizes chromosome-capping telomeric repeats using an active site in telomerase reverse transcriptase (TERT) and an integral RNA subunit template. The fundamental question of whether human telomerase catalytic activity requires cooperation across two TERT subunits remains under debate...

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Detalles Bibliográficos
Autores principales:	Wu, Robert Alexander, Dagdas, Yavuz S, Yilmaz, S Tunc, Yildiz, Ahmet, Collins, Kathleen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600948/ https://www.ncbi.nlm.nih.gov/pubmed/26457608 http://dx.doi.org/10.7554/eLife.08363

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