Novel anticancer agent, SQAP, binds to focal adhesion kinase and modulates its activity

SQAP is a novel and promising anticancer agent that was obtained by structural modifications from a natural compound. SQAP inhibits angiogenesis in vivo resulting in increased hypoxia and reduced tumor volume. In this study, the mechanism by which SQAP modifies the tumor microenvironment was reveale...

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Detalles Bibliográficos
Autores principales: Izaguirre-Carbonell, Jesus, Kawakubo, Hirofumi, Murata, Hiroshi, Tanabe, Atsushi, Takeuchi, Toshifumi, Kusayanagi, Tomoe, Tsukuda, Senko, Hirakawa, Takeshi, Iwabata, Kazuki, Kanai, Yoshihiro, Ohta, Keisuke, Miura, Masahiko, Sakaguchi, Kengo, Matsunaga, Sachihiro, Sahara, Hiroeki, Kamisuki, Shinji, Sugawara, Fumio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601023/
https://www.ncbi.nlm.nih.gov/pubmed/26456697
http://dx.doi.org/10.1038/srep15136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601023/
https://www.ncbi.nlm.nih.gov/pubmed/26456697
http://dx.doi.org/10.1038/srep15136

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