Frequency of Borrelia in Morphea Lesion by Polymerase Chain Reaction in Northeast of Iran

BACKGROUND: The etiology of morphea is still unknown. Borrelia spp. as a causative agent of morphea has been discussed since 1985, but the relationship remains uncertain. OBJECTIVES: We aimed to find the frequency of Borrelia in morphea lesions by polymerase chain reaction (PCR) in northeast of Iran...

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Autores principales: Yazdanpanah, Mohhamad Javad, Sharifi, Norieh, Khooei, Alireza, Banihashemi, Mahnaz, Khaje-Daluee, Mohammad, Shamsi, Azadeh, Ghazvini, Kiarash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601107/
https://www.ncbi.nlm.nih.gov/pubmed/26468360
http://dx.doi.org/10.5812/jjm.19730v2
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author Yazdanpanah, Mohhamad Javad
Sharifi, Norieh
Khooei, Alireza
Banihashemi, Mahnaz
Khaje-Daluee, Mohammad
Shamsi, Azadeh
Ghazvini, Kiarash
author_facet Yazdanpanah, Mohhamad Javad
Sharifi, Norieh
Khooei, Alireza
Banihashemi, Mahnaz
Khaje-Daluee, Mohammad
Shamsi, Azadeh
Ghazvini, Kiarash
author_sort Yazdanpanah, Mohhamad Javad
collection PubMed
description BACKGROUND: The etiology of morphea is still unknown. Borrelia spp. as a causative agent of morphea has been discussed since 1985, but the relationship remains uncertain. OBJECTIVES: We aimed to find the frequency of Borrelia in morphea lesions by polymerase chain reaction (PCR) in northeast of Iran. PATIENTS AND METHODS: Sixty six patients with morphea were prospectively included in the present study. For each patient, formalin-fixed, paraffin-embedded tissue blocks of skin lesion biopsies were examined for Borrelia spp. DNA using PCR. RESULTS: No Borrelia DNA was detected by PCR in skin lesions of patients with morphea. CONCLUSIONS: The result of this study showed no relationship between Borrelia infection and morphea lesions and in other word indicated that morphea, at least in Iran, is not caused by Borrelia spp.
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spelling pubmed-46011072015-10-14 Frequency of Borrelia in Morphea Lesion by Polymerase Chain Reaction in Northeast of Iran Yazdanpanah, Mohhamad Javad Sharifi, Norieh Khooei, Alireza Banihashemi, Mahnaz Khaje-Daluee, Mohammad Shamsi, Azadeh Ghazvini, Kiarash Jundishapur J Microbiol Research Article BACKGROUND: The etiology of morphea is still unknown. Borrelia spp. as a causative agent of morphea has been discussed since 1985, but the relationship remains uncertain. OBJECTIVES: We aimed to find the frequency of Borrelia in morphea lesions by polymerase chain reaction (PCR) in northeast of Iran. PATIENTS AND METHODS: Sixty six patients with morphea were prospectively included in the present study. For each patient, formalin-fixed, paraffin-embedded tissue blocks of skin lesion biopsies were examined for Borrelia spp. DNA using PCR. RESULTS: No Borrelia DNA was detected by PCR in skin lesions of patients with morphea. CONCLUSIONS: The result of this study showed no relationship between Borrelia infection and morphea lesions and in other word indicated that morphea, at least in Iran, is not caused by Borrelia spp. Kowsar 2015-08-27 /pmc/articles/PMC4601107/ /pubmed/26468360 http://dx.doi.org/10.5812/jjm.19730v2 Text en Copyright © 2015, Ahvaz Jundishapur University of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Yazdanpanah, Mohhamad Javad
Sharifi, Norieh
Khooei, Alireza
Banihashemi, Mahnaz
Khaje-Daluee, Mohammad
Shamsi, Azadeh
Ghazvini, Kiarash
Frequency of Borrelia in Morphea Lesion by Polymerase Chain Reaction in Northeast of Iran
title Frequency of Borrelia in Morphea Lesion by Polymerase Chain Reaction in Northeast of Iran
title_full Frequency of Borrelia in Morphea Lesion by Polymerase Chain Reaction in Northeast of Iran
title_fullStr Frequency of Borrelia in Morphea Lesion by Polymerase Chain Reaction in Northeast of Iran
title_full_unstemmed Frequency of Borrelia in Morphea Lesion by Polymerase Chain Reaction in Northeast of Iran
title_short Frequency of Borrelia in Morphea Lesion by Polymerase Chain Reaction in Northeast of Iran
title_sort frequency of borrelia in morphea lesion by polymerase chain reaction in northeast of iran
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601107/
https://www.ncbi.nlm.nih.gov/pubmed/26468360
http://dx.doi.org/10.5812/jjm.19730v2
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