Al(OH)(3) facilitated synthesis of water-soluble, magnetic, radiolabelled and fluorescent hydroxyapatite nanoparticles

Magnetic and fluorescent hydroxyapatite nanoparticles were synthesised using Al(OH)(3)-stabilised MnFe(2)O(4) or Fe(3)O(4) nanoparticles as precursors. They were readily and efficiently radiolabelled with (18)F. Bisphosphonate polyethylene glycol polymers were utilised to endow the nanoparticles wit...

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Detalles Bibliográficos
Autores principales: Cui, X., Green, M. A., Blower, P. J., Zhou, D., Yan, Y., Zhang, W., Djanashvili, K., Mathe, D., Veres, D. S., Szigeti, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601318/
https://www.ncbi.nlm.nih.gov/pubmed/25960059
http://dx.doi.org/10.1039/c5cc02259b
Descripción
Sumario:Magnetic and fluorescent hydroxyapatite nanoparticles were synthesised using Al(OH)(3)-stabilised MnFe(2)O(4) or Fe(3)O(4) nanoparticles as precursors. They were readily and efficiently radiolabelled with (18)F. Bisphosphonate polyethylene glycol polymers were utilised to endow the nanoparticles with excellent colloidal stability in water and to incorporate cyclam for high affinity labelling with (64)Cu.

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