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Non-conventional therapeutics for oral infections

As our knowledge of host-microbial interactions within the oral cavity increases, future treatments are likely to be more targeted. For example, efforts to target a single species or key virulence factors that they produce, while maintaining the natural balance of the resident oral microbiota that a...

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Detalles Bibliográficos
Autores principales: Allaker, Robert P, Ian Douglas, CW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601402/
https://www.ncbi.nlm.nih.gov/pubmed/25668296
http://dx.doi.org/10.4161/21505594.2014.983783
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author Allaker, Robert P
Ian Douglas, CW
author_facet Allaker, Robert P
Ian Douglas, CW
author_sort Allaker, Robert P
collection PubMed
description As our knowledge of host-microbial interactions within the oral cavity increases, future treatments are likely to be more targeted. For example, efforts to target a single species or key virulence factors that they produce, while maintaining the natural balance of the resident oral microbiota that acts to modulate the host immune response would be an advantage. Targeted approaches may be directed at the black-pigmented anaerobes, Porphyromonas gingivalis and Prevotella intermedia, associated with periodontitis. Such pigments provide an opportunity for targeted phototherapy with high-intensity monochromatic light. Functional inhibition approaches, including the use of enzyme inhibitors, are also being explored to control periodontitis. More general disruption of dental plaque through the use of enzymes and detergents, alone and in combination, shows much promise. The use of probiotics and prebiotics to improve gastrointestinal health has now led to an interest in using these approaches to control oral disease. More recently the potential of antimicrobial peptides and nanotechnology, through the application of nanoparticles with biocidal, anti-adhesive and delivery capabilities, has been explored. The aim of this review is to consider the current status as regards non-conventional treatment approaches for oral infections with particular emphasis on the plaque-related diseases.
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spelling pubmed-46014022016-02-03 Non-conventional therapeutics for oral infections Allaker, Robert P Ian Douglas, CW Virulence Review - Commissioned As our knowledge of host-microbial interactions within the oral cavity increases, future treatments are likely to be more targeted. For example, efforts to target a single species or key virulence factors that they produce, while maintaining the natural balance of the resident oral microbiota that acts to modulate the host immune response would be an advantage. Targeted approaches may be directed at the black-pigmented anaerobes, Porphyromonas gingivalis and Prevotella intermedia, associated with periodontitis. Such pigments provide an opportunity for targeted phototherapy with high-intensity monochromatic light. Functional inhibition approaches, including the use of enzyme inhibitors, are also being explored to control periodontitis. More general disruption of dental plaque through the use of enzymes and detergents, alone and in combination, shows much promise. The use of probiotics and prebiotics to improve gastrointestinal health has now led to an interest in using these approaches to control oral disease. More recently the potential of antimicrobial peptides and nanotechnology, through the application of nanoparticles with biocidal, anti-adhesive and delivery capabilities, has been explored. The aim of this review is to consider the current status as regards non-conventional treatment approaches for oral infections with particular emphasis on the plaque-related diseases. Taylor & Francis 2015-02-10 /pmc/articles/PMC4601402/ /pubmed/25668296 http://dx.doi.org/10.4161/21505594.2014.983783 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Review - Commissioned
Allaker, Robert P
Ian Douglas, CW
Non-conventional therapeutics for oral infections
title Non-conventional therapeutics for oral infections
title_full Non-conventional therapeutics for oral infections
title_fullStr Non-conventional therapeutics for oral infections
title_full_unstemmed Non-conventional therapeutics for oral infections
title_short Non-conventional therapeutics for oral infections
title_sort non-conventional therapeutics for oral infections
topic Review - Commissioned
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601402/
https://www.ncbi.nlm.nih.gov/pubmed/25668296
http://dx.doi.org/10.4161/21505594.2014.983783
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