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FHOD proteins in actin dynamics—a formin’ class of its own
Eukaryotic cells have evolved a variety of actin-binding proteins to regulate the architecture and the dynamics of the actin cytoskeleton in time and space. The Diaphanous-related formins (DRF) represent a diverse group of Rho-GTPase-regulated actin regulators that control a range of actin structure...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601495/ https://www.ncbi.nlm.nih.gov/pubmed/25483300 http://dx.doi.org/10.4161/21541248.2014.973765 |
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author | Bechtold, Meike Schultz, Jörg Bogdan, Sven |
author_facet | Bechtold, Meike Schultz, Jörg Bogdan, Sven |
author_sort | Bechtold, Meike |
collection | PubMed |
description | Eukaryotic cells have evolved a variety of actin-binding proteins to regulate the architecture and the dynamics of the actin cytoskeleton in time and space. The Diaphanous-related formins (DRF) represent a diverse group of Rho-GTPase-regulated actin regulators that control a range of actin structures composed of tightly-bundled, unbranched actin filaments as found in stress fibers and in filopodia. Under resting conditions, DRFs are auto-inhibited by an intra-molecular interaction between the C-terminal and the N-terminal domains. The auto-inhibition is thought to be released by binding of an activated RhoGTPase to the N-terminal GTPase-binding domain (GBD). However, there is growing evidence for more sophisticated variations from this simplified linear activation model. In this review we focus on the formin homology domain-containing proteins (FHOD), an unconventional group of DRFs. Recent findings on the molecular control and cellular functions of FHOD proteins in vivo are discussed in the light of the phylogeny of FHOD proteins. |
format | Online Article Text |
id | pubmed-4601495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-46014952016-02-03 FHOD proteins in actin dynamics—a formin’ class of its own Bechtold, Meike Schultz, Jörg Bogdan, Sven Small GTPases Mini-Review Eukaryotic cells have evolved a variety of actin-binding proteins to regulate the architecture and the dynamics of the actin cytoskeleton in time and space. The Diaphanous-related formins (DRF) represent a diverse group of Rho-GTPase-regulated actin regulators that control a range of actin structures composed of tightly-bundled, unbranched actin filaments as found in stress fibers and in filopodia. Under resting conditions, DRFs are auto-inhibited by an intra-molecular interaction between the C-terminal and the N-terminal domains. The auto-inhibition is thought to be released by binding of an activated RhoGTPase to the N-terminal GTPase-binding domain (GBD). However, there is growing evidence for more sophisticated variations from this simplified linear activation model. In this review we focus on the formin homology domain-containing proteins (FHOD), an unconventional group of DRFs. Recent findings on the molecular control and cellular functions of FHOD proteins in vivo are discussed in the light of the phylogeny of FHOD proteins. Taylor & Francis 2014-11-14 /pmc/articles/PMC4601495/ /pubmed/25483300 http://dx.doi.org/10.4161/21541248.2014.973765 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Mini-Review Bechtold, Meike Schultz, Jörg Bogdan, Sven FHOD proteins in actin dynamics—a formin’ class of its own |
title | FHOD proteins in actin dynamics—a formin’ class of its own |
title_full | FHOD proteins in actin dynamics—a formin’ class of its own |
title_fullStr | FHOD proteins in actin dynamics—a formin’ class of its own |
title_full_unstemmed | FHOD proteins in actin dynamics—a formin’ class of its own |
title_short | FHOD proteins in actin dynamics—a formin’ class of its own |
title_sort | fhod proteins in actin dynamics—a formin’ class of its own |
topic | Mini-Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601495/ https://www.ncbi.nlm.nih.gov/pubmed/25483300 http://dx.doi.org/10.4161/21541248.2014.973765 |
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