Stability of the Human Hsp90-p50(Cdc37) Chaperone Complex against Nucleotides and Hsp90 Inhibitors, and the Influence of Phosphorylation by Casein Kinase 2

The molecular chaperone Hsp90 is regulated by co-chaperones such as p50(Cdc37), which recruits a wide selection of client protein kinases. Targeted disruption of the Hsp90-p50(Cdc37) complex by protein–protein interaction (PPI) inhibitors has emerged as an alternative strategy to treat diseases char...

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Detalles Bibliográficos
Autores principales: Olesen, Sanne H., Ingles, Donna J., Zhu, Jin-Yi, Martin, Mathew P., Betzi, Stephane, Georg, Gunda I., Tash, Joseph S., Schönbrunn, Ernst
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601640/
https://www.ncbi.nlm.nih.gov/pubmed/25608045
http://dx.doi.org/10.3390/molecules20011643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601640/
https://www.ncbi.nlm.nih.gov/pubmed/25608045
http://dx.doi.org/10.3390/molecules20011643

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