Photovoltaic restoration of sight with high visual acuity

Patients with retinal degeneration lose sight due to gradual demise of photoreceptors. Electrical stimulation of the surviving retinal neurons provides an alternative route for delivery of visual information. We demonstrate that subretinal arrays with 70 μm photovoltaic pixels provide highly localiz...

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Autores principales: Lorach, Henri, Goetz, Georges, Smith, Richard, Lei, Xin, Mandel, Yossi, Kamins, Theodore, Mathieson, Keith, Huie, Philip, Harris, James, Sher, Alexander, Palanker, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601644/
https://www.ncbi.nlm.nih.gov/pubmed/25915832
http://dx.doi.org/10.1038/nm.3851
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author Lorach, Henri
Goetz, Georges
Smith, Richard
Lei, Xin
Mandel, Yossi
Kamins, Theodore
Mathieson, Keith
Huie, Philip
Harris, James
Sher, Alexander
Palanker, Daniel
author_facet Lorach, Henri
Goetz, Georges
Smith, Richard
Lei, Xin
Mandel, Yossi
Kamins, Theodore
Mathieson, Keith
Huie, Philip
Harris, James
Sher, Alexander
Palanker, Daniel
author_sort Lorach, Henri
collection PubMed
description Patients with retinal degeneration lose sight due to gradual demise of photoreceptors. Electrical stimulation of the surviving retinal neurons provides an alternative route for delivery of visual information. We demonstrate that subretinal arrays with 70 μm photovoltaic pixels provide highly localized stimulation, with electrical and visual receptive fields of comparable sizes in rat retinal ganglion cells. Similarly to normal vision, retinal response to prosthetic stimulation exhibits flicker fusion at high frequencies, adaptation to static images and non-linear spatial summation. In rats with retinal degeneration, these photovoltaic arrays provide spatial resolution of 64 ± 11 μm, corresponding to half of the normal visual acuity in pigmented rats. Ease of implantation of these wireless and modular arrays, combined with their high resolution opens the door to functional restoration of sight.
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spelling pubmed-46016442015-11-01 Photovoltaic restoration of sight with high visual acuity Lorach, Henri Goetz, Georges Smith, Richard Lei, Xin Mandel, Yossi Kamins, Theodore Mathieson, Keith Huie, Philip Harris, James Sher, Alexander Palanker, Daniel Nat Med Article Patients with retinal degeneration lose sight due to gradual demise of photoreceptors. Electrical stimulation of the surviving retinal neurons provides an alternative route for delivery of visual information. We demonstrate that subretinal arrays with 70 μm photovoltaic pixels provide highly localized stimulation, with electrical and visual receptive fields of comparable sizes in rat retinal ganglion cells. Similarly to normal vision, retinal response to prosthetic stimulation exhibits flicker fusion at high frequencies, adaptation to static images and non-linear spatial summation. In rats with retinal degeneration, these photovoltaic arrays provide spatial resolution of 64 ± 11 μm, corresponding to half of the normal visual acuity in pigmented rats. Ease of implantation of these wireless and modular arrays, combined with their high resolution opens the door to functional restoration of sight. 2015-04-27 2015-05 /pmc/articles/PMC4601644/ /pubmed/25915832 http://dx.doi.org/10.1038/nm.3851 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Lorach, Henri
Goetz, Georges
Smith, Richard
Lei, Xin
Mandel, Yossi
Kamins, Theodore
Mathieson, Keith
Huie, Philip
Harris, James
Sher, Alexander
Palanker, Daniel
Photovoltaic restoration of sight with high visual acuity
title Photovoltaic restoration of sight with high visual acuity
title_full Photovoltaic restoration of sight with high visual acuity
title_fullStr Photovoltaic restoration of sight with high visual acuity
title_full_unstemmed Photovoltaic restoration of sight with high visual acuity
title_short Photovoltaic restoration of sight with high visual acuity
title_sort photovoltaic restoration of sight with high visual acuity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601644/
https://www.ncbi.nlm.nih.gov/pubmed/25915832
http://dx.doi.org/10.1038/nm.3851
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