Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture

A replenishable source of insulin-producing cells has the potential to cure type 1 diabetes. Attempts to culture and expand pancreatic β-cells in vitro have resulted in their transition from insulin-producing epithelial cells to mesenchymal stromal cells (MSCs) with high proliferative capacity but d...

Descripción completa

Detalles Bibliográficos
Autores principales: Muir, Kenneth R., Lima, Maria João, Docherty, Hilary M., McGowan, Neil W. A., Forbes, Shareen, Heremans, Yves, Forbes, Stuart J., Heimberg, Harry, Casey, John, Docherty, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601732/
https://www.ncbi.nlm.nih.gov/pubmed/26457418
http://dx.doi.org/10.1371/journal.pone.0140352

Ejemplares similares

Ejemplares similares