Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing

Mutagenesis-based screens in mice are a powerful discovery platform to identify novel genes or gene functions associated with disease phenotypes. An N-ethyl-N-nitrosourea (ENU) mutagenesis screen induces single nucleotide variants randomly in the mouse genome. Subsequent phenotyping of mutant and wi...

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Detalles Bibliográficos
Autores principales: Simon, Michelle M., Moresco, Eva Marie Y., Bull, Katherine R., Kumar, Saumya, Mallon, Ann-Marie, Beutler, Bruce, Potter, Paul K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602060/
https://www.ncbi.nlm.nih.gov/pubmed/26449678
http://dx.doi.org/10.1007/s00335-015-9603-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602060/
https://www.ncbi.nlm.nih.gov/pubmed/26449678
http://dx.doi.org/10.1007/s00335-015-9603-x

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