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Cognitive training with and without additional physical activity in healthy older adults: cognitive effects, neurobiological mechanisms, and prediction of training success

Data is inconsistent concerning the question whether cognitive-physical training (CPT) yields stronger cognitive gains than cognitive training (CT). Effects of additional counseling, neurobiological mechanisms, and predictors have scarcely been studied. Healthy older adults were trained with CT (n =...

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Autores principales: Rahe, Julia, Becker, Jutta, Fink, Gereon R., Kessler, Josef, Kukolja, Juraj, Rahn, Andreas, Rosen, Jan B., Szabados, Florian, Wirth, Brunhilde, Kalbe, Elke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602086/
https://www.ncbi.nlm.nih.gov/pubmed/26528177
http://dx.doi.org/10.3389/fnagi.2015.00187
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author Rahe, Julia
Becker, Jutta
Fink, Gereon R.
Kessler, Josef
Kukolja, Juraj
Rahn, Andreas
Rosen, Jan B.
Szabados, Florian
Wirth, Brunhilde
Kalbe, Elke
author_facet Rahe, Julia
Becker, Jutta
Fink, Gereon R.
Kessler, Josef
Kukolja, Juraj
Rahn, Andreas
Rosen, Jan B.
Szabados, Florian
Wirth, Brunhilde
Kalbe, Elke
author_sort Rahe, Julia
collection PubMed
description Data is inconsistent concerning the question whether cognitive-physical training (CPT) yields stronger cognitive gains than cognitive training (CT). Effects of additional counseling, neurobiological mechanisms, and predictors have scarcely been studied. Healthy older adults were trained with CT (n = 20), CPT (n = 25), or CPT with counseling (CPT+C; n = 23). Cognition, physical fitness, BDNF, IGF-1, and VEGF were assessed at pre- and post-test. No interaction effects were found except for one effect showing that CPT+C led to stronger gains in verbal fluency than CPT (p = 0.03). However, this superiority could not be assigned to additional physical training gains. Low baseline cognitive performance and BDNF, not carrying apoE4, gains in physical fitness and the moderation of gains in physical fitness × gains in BDNF predicted training success. Although all types of interventions seem successful to enhance cognition, our data do not support the hypotheses that CPT shows superior CT gains compared to CT or that CPT+C adds merit to CPT. However, as CPT leads to additional gains in physical fitness which in turn is known to have positive impact on cognition in the long-term, CPT seems more beneficial. Training success can partly be predicted by neuropsychological, neurobiological, and genetic parameters. Unique Identifier: WHO ICTRP (http://www.who.int/ictrp); ID: DRKS00005194.
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spelling pubmed-46020862015-11-02 Cognitive training with and without additional physical activity in healthy older adults: cognitive effects, neurobiological mechanisms, and prediction of training success Rahe, Julia Becker, Jutta Fink, Gereon R. Kessler, Josef Kukolja, Juraj Rahn, Andreas Rosen, Jan B. Szabados, Florian Wirth, Brunhilde Kalbe, Elke Front Aging Neurosci Neuroscience Data is inconsistent concerning the question whether cognitive-physical training (CPT) yields stronger cognitive gains than cognitive training (CT). Effects of additional counseling, neurobiological mechanisms, and predictors have scarcely been studied. Healthy older adults were trained with CT (n = 20), CPT (n = 25), or CPT with counseling (CPT+C; n = 23). Cognition, physical fitness, BDNF, IGF-1, and VEGF were assessed at pre- and post-test. No interaction effects were found except for one effect showing that CPT+C led to stronger gains in verbal fluency than CPT (p = 0.03). However, this superiority could not be assigned to additional physical training gains. Low baseline cognitive performance and BDNF, not carrying apoE4, gains in physical fitness and the moderation of gains in physical fitness × gains in BDNF predicted training success. Although all types of interventions seem successful to enhance cognition, our data do not support the hypotheses that CPT shows superior CT gains compared to CT or that CPT+C adds merit to CPT. However, as CPT leads to additional gains in physical fitness which in turn is known to have positive impact on cognition in the long-term, CPT seems more beneficial. Training success can partly be predicted by neuropsychological, neurobiological, and genetic parameters. Unique Identifier: WHO ICTRP (http://www.who.int/ictrp); ID: DRKS00005194. Frontiers Media S.A. 2015-10-13 /pmc/articles/PMC4602086/ /pubmed/26528177 http://dx.doi.org/10.3389/fnagi.2015.00187 Text en Copyright © 2015 Rahe, Becker, Fink, Kessler, Kukolja, Rahn, Rosen, Szabados, Wirth and Kalbe. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Rahe, Julia
Becker, Jutta
Fink, Gereon R.
Kessler, Josef
Kukolja, Juraj
Rahn, Andreas
Rosen, Jan B.
Szabados, Florian
Wirth, Brunhilde
Kalbe, Elke
Cognitive training with and without additional physical activity in healthy older adults: cognitive effects, neurobiological mechanisms, and prediction of training success
title Cognitive training with and without additional physical activity in healthy older adults: cognitive effects, neurobiological mechanisms, and prediction of training success
title_full Cognitive training with and without additional physical activity in healthy older adults: cognitive effects, neurobiological mechanisms, and prediction of training success
title_fullStr Cognitive training with and without additional physical activity in healthy older adults: cognitive effects, neurobiological mechanisms, and prediction of training success
title_full_unstemmed Cognitive training with and without additional physical activity in healthy older adults: cognitive effects, neurobiological mechanisms, and prediction of training success
title_short Cognitive training with and without additional physical activity in healthy older adults: cognitive effects, neurobiological mechanisms, and prediction of training success
title_sort cognitive training with and without additional physical activity in healthy older adults: cognitive effects, neurobiological mechanisms, and prediction of training success
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602086/
https://www.ncbi.nlm.nih.gov/pubmed/26528177
http://dx.doi.org/10.3389/fnagi.2015.00187
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