Cargando…
Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism
Dopamine partial agonism and functional selectivity have been innovative strategies in the pharmacological treatment of schizophrenia and mood disorders and have shifted the concept of dopamine modulation beyond the established approach of dopamine D2 receptor (D2R) antagonism. Despite the fact that...
Autores principales: | de Bartolomeis, Andrea, Tomasetti, Carmine, Iasevoli, Felice |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602118/ https://www.ncbi.nlm.nih.gov/pubmed/26346901 http://dx.doi.org/10.1007/s40263-015-0278-3 |
Ejemplares similares
-
PM437. Spatial and temporal modulation of Homer1a gene expression at the post-synaptic density is related to D2R affinity and dose of antipsychotics: translational considerations for schizophrenia treatment strategies.
por: de Bartolomeis, Andrea, et al.
Publicado: (2016) -
Immediate-Early Genes Modulation by Antipsychotics: Translational Implications for a Putative Gateway to Drug-Induced Long-Term Brain Changes
por: de Bartolomeis, Andrea, et al.
Publicado: (2017) -
F234. TYPICAL AND ATYPICAL ANTIPSYCHOTICS’ D2R AFFINITY AND DOSES INFLUENCES POSTSYNAPTIC DENSITY BY MODULATING THE SPATIAL EXPRESSION OF HOMER1A A GENE HIGHLY IMPLICATED IN SYNAPTIC PLASTICITY AND PSYCHOSIS
por: Camilla, Avagliano, et al.
Publicado: (2018) -
Linking Inflammation, Aberrant Glutamate-Dopamine Interaction, and Post-synaptic Changes: Translational Relevance for Schizophrenia and Antipsychotic Treatment: a Systematic Review
por: de Bartolomeis, Andrea, et al.
Publicado: (2022) -
The Glutamatergic Aspects of Schizophrenia Molecular Pathophysiology: Role of the Postsynaptic Density, and Implications for Treatment
por: Iasevoli, Felice, et al.
Publicado: (2014)