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Defining order and timing of mutations during cancer progression: the TO-DAG probabilistic graphical model
Somatic mutations arise and accumulate both during tumor genesis and progression. However, the order in which mutations occur is an open question and the inference of the temporal ordering at the gene level could potentially impact on patient treatment. Thus, exploiting recent observations suggestin...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602157/ https://www.ncbi.nlm.nih.gov/pubmed/26528329 http://dx.doi.org/10.3389/fgene.2015.00309 |