Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization

In a mammalian oocyte, completion of meiosis is suspended until fertilization by a sperm, and the cell cycle is arrested by a biochemical activity called cytostatic factor (CSF). Emi2 is one of the CSFs, and it maintains the protein level of maturation promoting factor (MPF) by inhibiting ubiquitin...

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Detalles Bibliográficos
Autores principales: Jia, Jia-Lin, Han, Young-Hyun, Kim, Hak-Cheol, Ahn, Mija, Kwon, Jeong-Woo, Luo, Yibo, Gunasekaran, Pethaiah, Lee, Soo-Jae, Lee, Kyung S., Kyu Bang, Jeong, Kim, Nam-Hyung, Namgoong, Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602232/
https://www.ncbi.nlm.nih.gov/pubmed/26459104
http://dx.doi.org/10.1038/srep14626

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