Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits

Hallmarks of cancer, including rapid growth and aneuploidy, can result in non-oncogene addiction to the proteostasis network that can be exploited clinically. The defining example is the exquisite sensitivity of multiple myeloma (MM) to 20S proteasome inhibitors, such as carfilzomib. However, MM pat...

Descripción completa

Detalles Bibliográficos
Autores principales: Acosta-Alvear, Diego, Cho, Min Y, Wild, Thomas, Buchholz, Tonia J, Lerner, Alana G, Simakova, Olga, Hahn, Jamie, Korde, Neha, Landgren, Ola, Maric, Irina, Choudhary, Chunaram, Walter, Peter, Weissman, Jonathan S, Kampmann, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602331/
https://www.ncbi.nlm.nih.gov/pubmed/26327694
http://dx.doi.org/10.7554/eLife.08153

Ejemplares similares

Ejemplares similares