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Low Systolic Blood Pressure and Mortality From All-Cause and Vascular Diseases Among the Rural Elderly in Korea; Kangwha Cohort Study

The association between low systolic blood pressure (SBP) and vascular diseases is unclear. The aim of this study was to prospectively examine the association between SBP, especially low SBP, and mortality from all causes and vascular diseases among the elderly in Korea. Six thousand two hundred nin...

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Autores principales: Yi, Sang-Wook, Hong, Seri, Ohrr, Heechoul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602558/
https://www.ncbi.nlm.nih.gov/pubmed/25590834
http://dx.doi.org/10.1097/MD.0000000000000245
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author Yi, Sang-Wook
Hong, Seri
Ohrr, Heechoul
author_facet Yi, Sang-Wook
Hong, Seri
Ohrr, Heechoul
author_sort Yi, Sang-Wook
collection PubMed
description The association between low systolic blood pressure (SBP) and vascular diseases is unclear. The aim of this study was to prospectively examine the association between SBP, especially low SBP, and mortality from all causes and vascular diseases among the elderly in Korea. Six thousand two hundred ninety four residents in a rural community were followed-up for deaths from 1985 to 2008. The adjusted hazard ratios (aHR) and 95% confidence intervals were calculated by Cox proportional hazard model. A stratified analysis was conducted by age at enrolment. Among the elderly aged 65 and above, the lowest SBP (<100 mm Hg) group had an elevated aHR for mortality from vascular diseases (aHR = 2.1, 95% CI = 1.2–3.9) including stroke (aHR = 2.4, 95% CI = 0.9–6.3) and ischemic heart diseases (aHR = 5.1, 95% CI = 1.0–26.0) compared to those with SBP of 100–119 mm Hg, while higher SBP was associated with higher mortality. This J-curve association was generally maintained when analysis was restricted to those with fair or good self-rated health, or those with no known vascular diseases. In people below 65, increasing SBP nearly monotonically increased the mortality from all-cause and vascular diseases. Our results suggest that elderly persons with low SBP should be treated with caution, since low SBP may increase vascular mortality.
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spelling pubmed-46025582015-10-27 Low Systolic Blood Pressure and Mortality From All-Cause and Vascular Diseases Among the Rural Elderly in Korea; Kangwha Cohort Study Yi, Sang-Wook Hong, Seri Ohrr, Heechoul Medicine (Baltimore) 4400 The association between low systolic blood pressure (SBP) and vascular diseases is unclear. The aim of this study was to prospectively examine the association between SBP, especially low SBP, and mortality from all causes and vascular diseases among the elderly in Korea. Six thousand two hundred ninety four residents in a rural community were followed-up for deaths from 1985 to 2008. The adjusted hazard ratios (aHR) and 95% confidence intervals were calculated by Cox proportional hazard model. A stratified analysis was conducted by age at enrolment. Among the elderly aged 65 and above, the lowest SBP (<100 mm Hg) group had an elevated aHR for mortality from vascular diseases (aHR = 2.1, 95% CI = 1.2–3.9) including stroke (aHR = 2.4, 95% CI = 0.9–6.3) and ischemic heart diseases (aHR = 5.1, 95% CI = 1.0–26.0) compared to those with SBP of 100–119 mm Hg, while higher SBP was associated with higher mortality. This J-curve association was generally maintained when analysis was restricted to those with fair or good self-rated health, or those with no known vascular diseases. In people below 65, increasing SBP nearly monotonically increased the mortality from all-cause and vascular diseases. Our results suggest that elderly persons with low SBP should be treated with caution, since low SBP may increase vascular mortality. Wolters Kluwer Health 2015-01-16 /pmc/articles/PMC4602558/ /pubmed/25590834 http://dx.doi.org/10.1097/MD.0000000000000245 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-sa/4.0 This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0
spellingShingle 4400
Yi, Sang-Wook
Hong, Seri
Ohrr, Heechoul
Low Systolic Blood Pressure and Mortality From All-Cause and Vascular Diseases Among the Rural Elderly in Korea; Kangwha Cohort Study
title Low Systolic Blood Pressure and Mortality From All-Cause and Vascular Diseases Among the Rural Elderly in Korea; Kangwha Cohort Study
title_full Low Systolic Blood Pressure and Mortality From All-Cause and Vascular Diseases Among the Rural Elderly in Korea; Kangwha Cohort Study
title_fullStr Low Systolic Blood Pressure and Mortality From All-Cause and Vascular Diseases Among the Rural Elderly in Korea; Kangwha Cohort Study
title_full_unstemmed Low Systolic Blood Pressure and Mortality From All-Cause and Vascular Diseases Among the Rural Elderly in Korea; Kangwha Cohort Study
title_short Low Systolic Blood Pressure and Mortality From All-Cause and Vascular Diseases Among the Rural Elderly in Korea; Kangwha Cohort Study
title_sort low systolic blood pressure and mortality from all-cause and vascular diseases among the rural elderly in korea; kangwha cohort study
topic 4400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602558/
https://www.ncbi.nlm.nih.gov/pubmed/25590834
http://dx.doi.org/10.1097/MD.0000000000000245
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