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D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis

No early serum marker of disease severity contributes to the treatment decision-making process of acute superior mesenteric venous thrombosis (ASMVT). This study aims to assess the value of serum D-dimer level in the first 3 days after admission as a severity marker of ASMVT patients. From May 2010...

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Autores principales: Yang, Shuofei, Fan, Xinxin, Ding, Weiwei, Liu, Baochen, Meng, Jiaxiang, Wang, Kai, Wu, Xingjiang, Li, Jieshou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602603/
https://www.ncbi.nlm.nih.gov/pubmed/25546667
http://dx.doi.org/10.1097/MD.0000000000000270
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author Yang, Shuofei
Fan, Xinxin
Ding, Weiwei
Liu, Baochen
Meng, Jiaxiang
Wang, Kai
Wu, Xingjiang
Li, Jieshou
author_facet Yang, Shuofei
Fan, Xinxin
Ding, Weiwei
Liu, Baochen
Meng, Jiaxiang
Wang, Kai
Wu, Xingjiang
Li, Jieshou
author_sort Yang, Shuofei
collection PubMed
description No early serum marker of disease severity contributes to the treatment decision-making process of acute superior mesenteric venous thrombosis (ASMVT). This study aims to assess the value of serum D-dimer level in the first 3 days after admission as a severity marker of ASMVT patients. From May 2010 to June 2014, 50 consecutive patients of ASMVT were enrolled in this observational study. The serum D-dimer level was measured on a daily basis during the first 3 days after admission as well as other laboratory-testing parameters, clinical score, and outcome variables recorded during the same period. The maximum and mean D-dimer values were analyzed and compared with other potential markers for prediction of multiple-organ dysfunction syndrome (MODS) and short-bowel syndrome (SBS). The correlation of D-dimer level with other potential severity markers and inflammation parameters were also studied. Both maximum and mean D-dimer level during the first 3 days of admission were significantly higher in patients with several clinical variables such as death within 30 days, bowel resection, sepsis, abdominal compartment syndrome, MODS, and SBS. In addition, serum D-dimer level showed precise prediction for MODS and SBS, greater than l-lactate and intestinal-type fatty acid-binding protein (I-FABP). The D-dimer level was correlated well with l-lactate, I-FABP, and APACHE II score on the first 3 days of admission. Poor correlation of D-dimer level and inflammation parameters, white blood cell count, and C-reactive protein level, was detected. D-dimer level could be an effective, early, and specific serum marker indicating the clinical evolution and outcome of ASMVT.
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spelling pubmed-46026032015-10-27 D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis Yang, Shuofei Fan, Xinxin Ding, Weiwei Liu, Baochen Meng, Jiaxiang Wang, Kai Wu, Xingjiang Li, Jieshou Medicine (Baltimore) 4100 No early serum marker of disease severity contributes to the treatment decision-making process of acute superior mesenteric venous thrombosis (ASMVT). This study aims to assess the value of serum D-dimer level in the first 3 days after admission as a severity marker of ASMVT patients. From May 2010 to June 2014, 50 consecutive patients of ASMVT were enrolled in this observational study. The serum D-dimer level was measured on a daily basis during the first 3 days after admission as well as other laboratory-testing parameters, clinical score, and outcome variables recorded during the same period. The maximum and mean D-dimer values were analyzed and compared with other potential markers for prediction of multiple-organ dysfunction syndrome (MODS) and short-bowel syndrome (SBS). The correlation of D-dimer level with other potential severity markers and inflammation parameters were also studied. Both maximum and mean D-dimer level during the first 3 days of admission were significantly higher in patients with several clinical variables such as death within 30 days, bowel resection, sepsis, abdominal compartment syndrome, MODS, and SBS. In addition, serum D-dimer level showed precise prediction for MODS and SBS, greater than l-lactate and intestinal-type fatty acid-binding protein (I-FABP). The D-dimer level was correlated well with l-lactate, I-FABP, and APACHE II score on the first 3 days of admission. Poor correlation of D-dimer level and inflammation parameters, white blood cell count, and C-reactive protein level, was detected. D-dimer level could be an effective, early, and specific serum marker indicating the clinical evolution and outcome of ASMVT. Wolters Kluwer Health 2014-12-02 /pmc/articles/PMC4602603/ /pubmed/25546667 http://dx.doi.org/10.1097/MD.0000000000000270 Text en Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4100
Yang, Shuofei
Fan, Xinxin
Ding, Weiwei
Liu, Baochen
Meng, Jiaxiang
Wang, Kai
Wu, Xingjiang
Li, Jieshou
D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis
title D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis
title_full D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis
title_fullStr D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis
title_full_unstemmed D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis
title_short D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis
title_sort d-dimer as an early marker of severity in patients with acute superior mesenteric venous thrombosis
topic 4100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602603/
https://www.ncbi.nlm.nih.gov/pubmed/25546667
http://dx.doi.org/10.1097/MD.0000000000000270
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