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D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis
No early serum marker of disease severity contributes to the treatment decision-making process of acute superior mesenteric venous thrombosis (ASMVT). This study aims to assess the value of serum D-dimer level in the first 3 days after admission as a severity marker of ASMVT patients. From May 2010...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602603/ https://www.ncbi.nlm.nih.gov/pubmed/25546667 http://dx.doi.org/10.1097/MD.0000000000000270 |
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author | Yang, Shuofei Fan, Xinxin Ding, Weiwei Liu, Baochen Meng, Jiaxiang Wang, Kai Wu, Xingjiang Li, Jieshou |
author_facet | Yang, Shuofei Fan, Xinxin Ding, Weiwei Liu, Baochen Meng, Jiaxiang Wang, Kai Wu, Xingjiang Li, Jieshou |
author_sort | Yang, Shuofei |
collection | PubMed |
description | No early serum marker of disease severity contributes to the treatment decision-making process of acute superior mesenteric venous thrombosis (ASMVT). This study aims to assess the value of serum D-dimer level in the first 3 days after admission as a severity marker of ASMVT patients. From May 2010 to June 2014, 50 consecutive patients of ASMVT were enrolled in this observational study. The serum D-dimer level was measured on a daily basis during the first 3 days after admission as well as other laboratory-testing parameters, clinical score, and outcome variables recorded during the same period. The maximum and mean D-dimer values were analyzed and compared with other potential markers for prediction of multiple-organ dysfunction syndrome (MODS) and short-bowel syndrome (SBS). The correlation of D-dimer level with other potential severity markers and inflammation parameters were also studied. Both maximum and mean D-dimer level during the first 3 days of admission were significantly higher in patients with several clinical variables such as death within 30 days, bowel resection, sepsis, abdominal compartment syndrome, MODS, and SBS. In addition, serum D-dimer level showed precise prediction for MODS and SBS, greater than l-lactate and intestinal-type fatty acid-binding protein (I-FABP). The D-dimer level was correlated well with l-lactate, I-FABP, and APACHE II score on the first 3 days of admission. Poor correlation of D-dimer level and inflammation parameters, white blood cell count, and C-reactive protein level, was detected. D-dimer level could be an effective, early, and specific serum marker indicating the clinical evolution and outcome of ASMVT. |
format | Online Article Text |
id | pubmed-4602603 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-46026032015-10-27 D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis Yang, Shuofei Fan, Xinxin Ding, Weiwei Liu, Baochen Meng, Jiaxiang Wang, Kai Wu, Xingjiang Li, Jieshou Medicine (Baltimore) 4100 No early serum marker of disease severity contributes to the treatment decision-making process of acute superior mesenteric venous thrombosis (ASMVT). This study aims to assess the value of serum D-dimer level in the first 3 days after admission as a severity marker of ASMVT patients. From May 2010 to June 2014, 50 consecutive patients of ASMVT were enrolled in this observational study. The serum D-dimer level was measured on a daily basis during the first 3 days after admission as well as other laboratory-testing parameters, clinical score, and outcome variables recorded during the same period. The maximum and mean D-dimer values were analyzed and compared with other potential markers for prediction of multiple-organ dysfunction syndrome (MODS) and short-bowel syndrome (SBS). The correlation of D-dimer level with other potential severity markers and inflammation parameters were also studied. Both maximum and mean D-dimer level during the first 3 days of admission were significantly higher in patients with several clinical variables such as death within 30 days, bowel resection, sepsis, abdominal compartment syndrome, MODS, and SBS. In addition, serum D-dimer level showed precise prediction for MODS and SBS, greater than l-lactate and intestinal-type fatty acid-binding protein (I-FABP). The D-dimer level was correlated well with l-lactate, I-FABP, and APACHE II score on the first 3 days of admission. Poor correlation of D-dimer level and inflammation parameters, white blood cell count, and C-reactive protein level, was detected. D-dimer level could be an effective, early, and specific serum marker indicating the clinical evolution and outcome of ASMVT. Wolters Kluwer Health 2014-12-02 /pmc/articles/PMC4602603/ /pubmed/25546667 http://dx.doi.org/10.1097/MD.0000000000000270 Text en Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 4100 Yang, Shuofei Fan, Xinxin Ding, Weiwei Liu, Baochen Meng, Jiaxiang Wang, Kai Wu, Xingjiang Li, Jieshou D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis |
title | D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis |
title_full | D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis |
title_fullStr | D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis |
title_full_unstemmed | D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis |
title_short | D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis |
title_sort | d-dimer as an early marker of severity in patients with acute superior mesenteric venous thrombosis |
topic | 4100 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602603/ https://www.ncbi.nlm.nih.gov/pubmed/25546667 http://dx.doi.org/10.1097/MD.0000000000000270 |
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