Long-Term Cancer-Free Survival after Infusion of Autologous Cord Blood Cells for Rejection-Unrelated Cord Blood Graft After Myeloablative Conditioning for t-MDS: A Case Report

Autologous cord blood transplantations are rarely applied in patients with hematologic as well as metastatic solid cancers since contamination of malignant clones is a concern. We report a case of therapy-related myelodysplasia after metastatic neuroblastoma who suffered from graft rejection and lif...

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Autores principales: Chen, Wei-Ting, Fang, Li-Hua, Chen, Rong-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
5700
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602716/
https://www.ncbi.nlm.nih.gov/pubmed/25654378
http://dx.doi.org/10.1097/MD.0000000000000438
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author Chen, Wei-Ting
Fang, Li-Hua
Chen, Rong-Long
author_facet Chen, Wei-Ting
Fang, Li-Hua
Chen, Rong-Long
author_sort Chen, Wei-Ting
collection PubMed
description Autologous cord blood transplantations are rarely applied in patients with hematologic as well as metastatic solid cancers since contamination of malignant clones is a concern. We report a case of therapy-related myelodysplasia after metastatic neuroblastoma who suffered from graft rejection and life-threatening infections after a myeloablative unrelated cord blood transplantation. The patient experiences long-term survival, free from leukemia/neuroblastoma after infusion of autologous cord blood cells. It suggests that autologous cord blood transplantation after high dose therapy might be a curative strategy for certain hematologic or metastatic solid cancers.
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spelling pubmed-46027162015-10-27 Long-Term Cancer-Free Survival after Infusion of Autologous Cord Blood Cells for Rejection-Unrelated Cord Blood Graft After Myeloablative Conditioning for t-MDS: A Case Report Chen, Wei-Ting Fang, Li-Hua Chen, Rong-Long Medicine (Baltimore) 5700 Autologous cord blood transplantations are rarely applied in patients with hematologic as well as metastatic solid cancers since contamination of malignant clones is a concern. We report a case of therapy-related myelodysplasia after metastatic neuroblastoma who suffered from graft rejection and life-threatening infections after a myeloablative unrelated cord blood transplantation. The patient experiences long-term survival, free from leukemia/neuroblastoma after infusion of autologous cord blood cells. It suggests that autologous cord blood transplantation after high dose therapy might be a curative strategy for certain hematologic or metastatic solid cancers. Wolters Kluwer Health 2015-02-06 /pmc/articles/PMC4602716/ /pubmed/25654378 http://dx.doi.org/10.1097/MD.0000000000000438 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5700
Chen, Wei-Ting
Fang, Li-Hua
Chen, Rong-Long
Long-Term Cancer-Free Survival after Infusion of Autologous Cord Blood Cells for Rejection-Unrelated Cord Blood Graft After Myeloablative Conditioning for t-MDS: A Case Report
title Long-Term Cancer-Free Survival after Infusion of Autologous Cord Blood Cells for Rejection-Unrelated Cord Blood Graft After Myeloablative Conditioning for t-MDS: A Case Report
title_full Long-Term Cancer-Free Survival after Infusion of Autologous Cord Blood Cells for Rejection-Unrelated Cord Blood Graft After Myeloablative Conditioning for t-MDS: A Case Report
title_fullStr Long-Term Cancer-Free Survival after Infusion of Autologous Cord Blood Cells for Rejection-Unrelated Cord Blood Graft After Myeloablative Conditioning for t-MDS: A Case Report
title_full_unstemmed Long-Term Cancer-Free Survival after Infusion of Autologous Cord Blood Cells for Rejection-Unrelated Cord Blood Graft After Myeloablative Conditioning for t-MDS: A Case Report
title_short Long-Term Cancer-Free Survival after Infusion of Autologous Cord Blood Cells for Rejection-Unrelated Cord Blood Graft After Myeloablative Conditioning for t-MDS: A Case Report
title_sort long-term cancer-free survival after infusion of autologous cord blood cells for rejection-unrelated cord blood graft after myeloablative conditioning for t-mds: a case report
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602716/
https://www.ncbi.nlm.nih.gov/pubmed/25654378
http://dx.doi.org/10.1097/MD.0000000000000438
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