Effects of Abiraterone Acetate on Chronic Kidney Disease in 2 Patients With Metastatic Castration-resistant Prostate Cancer

Prostate cancer is the second leading cause of cancer-related death in men in most Western countries. In this report, we present 2 cases of metastatic castration-resistant prostate cancer and chronic kidney disease. Both patients underwent and developed clinical resistance to androgen-deprivation th...

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Autores principales: Francini, Edoardo, Petrioli, Roberto, Fiaschi, Anna Ida, Laera, Letizia, Roviello, Giandomenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2014
Materias:
5700
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602778/
https://www.ncbi.nlm.nih.gov/pubmed/25501058
http://dx.doi.org/10.1097/MD.0000000000000163
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author Francini, Edoardo
Petrioli, Roberto
Fiaschi, Anna Ida
Laera, Letizia
Roviello, Giandomenico
author_facet Francini, Edoardo
Petrioli, Roberto
Fiaschi, Anna Ida
Laera, Letizia
Roviello, Giandomenico
author_sort Francini, Edoardo
collection PubMed
description Prostate cancer is the second leading cause of cancer-related death in men in most Western countries. In this report, we present 2 cases of metastatic castration-resistant prostate cancer and chronic kidney disease. Both patients underwent and developed clinical resistance to androgen-deprivation therapy. Subsequently, the patients were treated with the conventional chemotherapeutic approach, which resulted in the worsening of renal function and performance status. Therefore, we opted for treatment with abiraterone acetate, and the patients exhibited improvements in renal function with good response of the disease.
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spelling pubmed-46027782015-10-27 Effects of Abiraterone Acetate on Chronic Kidney Disease in 2 Patients With Metastatic Castration-resistant Prostate Cancer Francini, Edoardo Petrioli, Roberto Fiaschi, Anna Ida Laera, Letizia Roviello, Giandomenico Medicine (Baltimore) 5700 Prostate cancer is the second leading cause of cancer-related death in men in most Western countries. In this report, we present 2 cases of metastatic castration-resistant prostate cancer and chronic kidney disease. Both patients underwent and developed clinical resistance to androgen-deprivation therapy. Subsequently, the patients were treated with the conventional chemotherapeutic approach, which resulted in the worsening of renal function and performance status. Therefore, we opted for treatment with abiraterone acetate, and the patients exhibited improvements in renal function with good response of the disease. Wolters Kluwer Health 2014-12-12 /pmc/articles/PMC4602778/ /pubmed/25501058 http://dx.doi.org/10.1097/MD.0000000000000163 Text en Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5700
Francini, Edoardo
Petrioli, Roberto
Fiaschi, Anna Ida
Laera, Letizia
Roviello, Giandomenico
Effects of Abiraterone Acetate on Chronic Kidney Disease in 2 Patients With Metastatic Castration-resistant Prostate Cancer
title Effects of Abiraterone Acetate on Chronic Kidney Disease in 2 Patients With Metastatic Castration-resistant Prostate Cancer
title_full Effects of Abiraterone Acetate on Chronic Kidney Disease in 2 Patients With Metastatic Castration-resistant Prostate Cancer
title_fullStr Effects of Abiraterone Acetate on Chronic Kidney Disease in 2 Patients With Metastatic Castration-resistant Prostate Cancer
title_full_unstemmed Effects of Abiraterone Acetate on Chronic Kidney Disease in 2 Patients With Metastatic Castration-resistant Prostate Cancer
title_short Effects of Abiraterone Acetate on Chronic Kidney Disease in 2 Patients With Metastatic Castration-resistant Prostate Cancer
title_sort effects of abiraterone acetate on chronic kidney disease in 2 patients with metastatic castration-resistant prostate cancer
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602778/
https://www.ncbi.nlm.nih.gov/pubmed/25501058
http://dx.doi.org/10.1097/MD.0000000000000163
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