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The Incidence Rate, High-Risk Factors, and Short- and Long-Term Adverse Outcomes of Fetal Growth Restriction: A Report From Mainland China

To investigate the incidence and high-risk factors of fetal growth restriction (FGR) in Mainland China and determine the adverse effects of this condition on fetal-neonatal health. This study was a retrospective chart review. We investigated the incidence rate of FGR using a retrospective analysis o...

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Autores principales: Liu, Jing, Wang, Xiao-Feng, Wang, Yan, Wang, Hua-Wei, Liu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602786/
https://www.ncbi.nlm.nih.gov/pubmed/25501078
http://dx.doi.org/10.1097/MD.0000000000000210
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author Liu, Jing
Wang, Xiao-Feng
Wang, Yan
Wang, Hua-Wei
Liu, Ying
author_facet Liu, Jing
Wang, Xiao-Feng
Wang, Yan
Wang, Hua-Wei
Liu, Ying
author_sort Liu, Jing
collection PubMed
description To investigate the incidence and high-risk factors of fetal growth restriction (FGR) in Mainland China and determine the adverse effects of this condition on fetal-neonatal health. This study was a retrospective chart review. We investigated the incidence rate of FGR using a retrospective analysis of clinical data obtained from mothers and newborns from 7 hospitals in Mainland China from January 1 to December 31, 2011. The short-term outcomes of FGR were analyzed based on data obtained from the neonatal intensive-care unit (NICU) of Bayi Children's Hospital. The long-term outcomes of FGR were determined after a follow-up study of 125 cases of FGR in children at 18 months. The physical development index, mental development index (MDI), and psychomotor development index (PDI) were compared between FGR patients and controls. The incidence of FGR was 8.77%. The incidence of FGR was significantly higher in females than in males (9.80% vs 7.84%, P < 0.05). The incidence of FGR in preterm infants was higher than that in full-term infants (16.43% vs 7.87%, P < 0.01). Chronic hypertension, abnormal amniotic fluid, and umbilical cord abnormalities were independent factors of FGR. A significantly higher incidence of complications, including hypoglycemia, asphyxia, hypoxic-ischemic encephalopathy, gastrointestinal bleeding, congenital malformations, polycythemia, lung hemorrhage, apnea, congenital heart disease, and disseminated intravascular coagulation, was observed in FGR patients than in controls. The FGR prolonged the duration of the hospital stay and markedly increased hospitalization expenses (P < 0.05). Children with FGR showed catch-up growth, which reached the level of the control group after 1.5 years, but these individuals still had lower MDI and PDI scores. The incidence rate of FGR in Mainland China was 8.77%. It has a significantly adverse effect on fetal-neonatal health and cognitive development.
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spelling pubmed-46027862015-10-27 The Incidence Rate, High-Risk Factors, and Short- and Long-Term Adverse Outcomes of Fetal Growth Restriction: A Report From Mainland China Liu, Jing Wang, Xiao-Feng Wang, Yan Wang, Hua-Wei Liu, Ying Medicine (Baltimore) 6600 To investigate the incidence and high-risk factors of fetal growth restriction (FGR) in Mainland China and determine the adverse effects of this condition on fetal-neonatal health. This study was a retrospective chart review. We investigated the incidence rate of FGR using a retrospective analysis of clinical data obtained from mothers and newborns from 7 hospitals in Mainland China from January 1 to December 31, 2011. The short-term outcomes of FGR were analyzed based on data obtained from the neonatal intensive-care unit (NICU) of Bayi Children's Hospital. The long-term outcomes of FGR were determined after a follow-up study of 125 cases of FGR in children at 18 months. The physical development index, mental development index (MDI), and psychomotor development index (PDI) were compared between FGR patients and controls. The incidence of FGR was 8.77%. The incidence of FGR was significantly higher in females than in males (9.80% vs 7.84%, P < 0.05). The incidence of FGR in preterm infants was higher than that in full-term infants (16.43% vs 7.87%, P < 0.01). Chronic hypertension, abnormal amniotic fluid, and umbilical cord abnormalities were independent factors of FGR. A significantly higher incidence of complications, including hypoglycemia, asphyxia, hypoxic-ischemic encephalopathy, gastrointestinal bleeding, congenital malformations, polycythemia, lung hemorrhage, apnea, congenital heart disease, and disseminated intravascular coagulation, was observed in FGR patients than in controls. The FGR prolonged the duration of the hospital stay and markedly increased hospitalization expenses (P < 0.05). Children with FGR showed catch-up growth, which reached the level of the control group after 1.5 years, but these individuals still had lower MDI and PDI scores. The incidence rate of FGR in Mainland China was 8.77%. It has a significantly adverse effect on fetal-neonatal health and cognitive development. Wolters Kluwer Health 2014-12-12 /pmc/articles/PMC4602786/ /pubmed/25501078 http://dx.doi.org/10.1097/MD.0000000000000210 Text en Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 6600
Liu, Jing
Wang, Xiao-Feng
Wang, Yan
Wang, Hua-Wei
Liu, Ying
The Incidence Rate, High-Risk Factors, and Short- and Long-Term Adverse Outcomes of Fetal Growth Restriction: A Report From Mainland China
title The Incidence Rate, High-Risk Factors, and Short- and Long-Term Adverse Outcomes of Fetal Growth Restriction: A Report From Mainland China
title_full The Incidence Rate, High-Risk Factors, and Short- and Long-Term Adverse Outcomes of Fetal Growth Restriction: A Report From Mainland China
title_fullStr The Incidence Rate, High-Risk Factors, and Short- and Long-Term Adverse Outcomes of Fetal Growth Restriction: A Report From Mainland China
title_full_unstemmed The Incidence Rate, High-Risk Factors, and Short- and Long-Term Adverse Outcomes of Fetal Growth Restriction: A Report From Mainland China
title_short The Incidence Rate, High-Risk Factors, and Short- and Long-Term Adverse Outcomes of Fetal Growth Restriction: A Report From Mainland China
title_sort incidence rate, high-risk factors, and short- and long-term adverse outcomes of fetal growth restriction: a report from mainland china
topic 6600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602786/
https://www.ncbi.nlm.nih.gov/pubmed/25501078
http://dx.doi.org/10.1097/MD.0000000000000210
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